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- W2365105767 abstract "ObjectiveTo investigate the protective effect of pyrroloquinoline quinone (PQQ) on damage of hippocampal neurons induced by NMDA.MethodsHippocampal neurons were cultured in vitro and NMDA was used to induce neurotoxicity 8 d after, while PQQ were used or not before. The metamorphosis of hippocampal neurons was observed under the microscope. Intracellular calcium levels was measured by confocal laser microscopy. ResultsThe intracellular Ca~ 2+ level increased rapidly after exposure to 0.1 mmol/L NMDA and resulted in neuronal necrosis and apoptosis. Otherwise, pretreatment of the cultured neurons with PQQ reduced the increase of the intracellular Ca~ 2+ level and the neuronal necrosis or apoptosis induced by NMDA.ConclusionPQQ can protect hippocampal neurons from damage induced by NMDA." @default.
- W2365105767 created "2016-06-24" @default.
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- W2365105767 date "2005-01-01" @default.
- W2365105767 modified "2023-09-25" @default.
- W2365105767 title "Protective effect of pyrroloquinoline quinone on damage of hippocampal neurons induced by NMDA in rats" @default.
- W2365105767 hasPublicationYear "2005" @default.
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