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- W2365697778 abstract "Objective To investigate the possible mechanism of the radiation by Gamma knife on the expression of the two proteins:GAFP and Cx43,separating in cultured rat astrocytes. Methods Astrocytes from rats were cultured and irradiated by gamma knife. A total of rat astrocytes were divided into 2 groups:control group and gamma knife-treatment group. The gamma knife-treatment group wasfurther divided into nine subgroups at different doses (4～36Gy), and the changes in GFAP and Cx43 expression were detected by immunofluorescence methods 72h after radiation by Gamma knife.Results Compared with the normal control group, GFAP expression in a dose-dependent manner was found in the gamma knife irradiation group,its expression was elevated at 16Gy more than that in normal group, approaching its peak value in 32Gy group, and the levels of gamma knife irradiation group were statistically diferent from those in the normal control group (P0.05). Cx43 expression in a dose-dependent manner was lowered. It became lower than in normal group at 12Gy, reached the lowest In 32Gy group. Conclusions The expression of GFAP can be increased and expression of Cx43 are depressed after gamma knife treatment. Cx43 may play a important role in Astrocytic proliferation and brain radiation injury after gamma knife radiosurgery as well as GFAP did." @default.
- W2365697778 created "2016-06-24" @default.
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- W2365697778 date "2009-01-01" @default.
- W2365697778 modified "2023-09-23" @default.
- W2365697778 title "Radiation-Induced Changes of connexin43(Cx43) and GFAP expression in cultured rat astrocytes after irradiation by gamma knife" @default.
- W2365697778 hasPublicationYear "2009" @default.
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