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- W2365713079 abstract "Objective:To investigate the effect of yiqihuoxue prescriptions on expression of P27 after carotid artery vascular injury in rats.Methods:Rats(n=60)were randomly divided into 5 groups: the model group;the aspirin group;the low-dose Yiqihuoxue group,the mid-dose Yiqihuoxue group and the high-dose Yiqihuoxue group.All of the rats fed up with hypercholesterolemic diet for 30 days,then the 2.Of balloon catheter injury was perfomed through the right femoral artery into the left common carotid artery of rats,the balloon was inflated and deflated 3 times.The rats was given drugs into stomach from 1 day before injury and to 14days and 28days after injury.Around 6 rats from each group were euthanized by exsanguination at appropriate time point.The injuried left common carotid arteries were carefully removed and harvested for SABC staining.The expression of P27 was observed by immunohistochemical technique.Results:The expression of P27 at the 14th day after injury was minimum,and increased obviously when given Huoxueyiqi prescriptions,compared with the model group(P0.05).Conclusion:Huoxueyiqi prescriptions could effectively decrease intimal VSMCs proliferation after balloon injury,which maybe associated with inhibiting the proliferation of VSMCs through increasing the expression of P27." @default.
- W2365713079 created "2016-06-24" @default.
- W2365713079 creator A5021791473 @default.
- W2365713079 date "2009-01-01" @default.
- W2365713079 modified "2023-09-23" @default.
- W2365713079 title "Effect of Yiqihuoxue Prescriptions on Expression of P27 After Carotid Artery Balloon Injury in Rats" @default.
- W2365713079 hasPublicationYear "2009" @default.
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