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• W2369901230 abstract "Objective To identify loci influencing susceptibility to late onset type 2 diabetes mellitus by genome scan method. Methods Genome scan method based on fluorescence labeled microsatellite markers with multiplex PCR system was used to identify loci influencing susceptibility to late onset type 2 diabetes mellitus. The 63 pairs of primers of microsatellits DNA markers used in this study were provided by Perkin Elmer Applied Biosystems Division. 264 samples from 58 pedigrees were studied. Among these samples, 152 were collected from diabetic patients including 74 affected siblings forming 45 affected sib pairs and 112 from non diabetic members. Chromosome 1, 12, 18, 20 were scanned and linkage analysis were carried out with GENEHUNTER (version 2) software. Results Non parametric linkage analysis showed evidence for linkage at several chromosome regions with type 2 diabetes mellitus, including D1S2868 at 1p31, with NPL value of 1.192 and p value of 0.045, and D20S177, D20S889, D20S196 at 20p13, 20p13 and 20q13.3 respectively, withNPL valueof1.362,1.360,and 1.199 respectively and p value of 0.030, 0.030 and 0.049 respectively. Conclusion Loci on region 1p31, 20p13 and 20q13.3 may influence susceptibility to type 2 diabetes." @default.
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• W2369901230 date "2000-01-01" @default.
• W2369901230 modified "2023-09-27" @default.
• W2369901230 title "A genome scan for late onset type-2 diabetes susceptibility loci in Chinese: a preliminary report" @default.
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