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- W2370952357 abstract "Objective To investigate the clinical outcome and toxicity of long term continuous infusion(CI)of low dose of 5-FU for the patients who were relapsed or resistant to short term continuous infusion 5-Fu or xeloda-based chemotherapy.Methods 19 patients who were relapsed or resistant to short term continuous infusion 5-Fu or xeloda-based chemotherapy were subjected to long term CI 200 mg/(m2·d)5-FU through portable pumps until disease progression.After each 30-day course of the treatment,the efficacy and toxicity were evaluated by Response Evaluation Criteria in Solid Tumors(RECIST)and the NCI anticancer drug toxicity criteria,respectively.Results Among all the 19 evaluable cases,there were 0 complete remission(CR),2 partial remission(PR),8 stable disease(SD),and 9 progressive disease(PD).The response rate(RR=CR+PR)and the clinical benefit rate(CR+PR+SD)were therefore 10.5% and 52.6%,respectively.Toxicities were mainly grade Ⅰ-Ⅱ mucositis and hand-foot syndrome.Conclusion The long term protracted CI of low-dose 5-FU has a better effect on refractory or relapsed patients failed to 5-Fu or xeloda-based chemotherapy." @default.
- W2370952357 created "2016-06-24" @default.
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- W2370952357 date "2010-01-01" @default.
- W2370952357 modified "2023-09-25" @default.
- W2370952357 title "Long Term Continuous Intravenous Drip Infusion of Low-Dose of 5-Fluorouracil for Advanced Malignant Tumors" @default.
- W2370952357 hasPublicationYear "2010" @default.
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