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- W2372384259 abstract "Objective To investigate the effects of Selenium chiston(Sc) on proliferation of human multidrug resistance chronic myelocytic leukemia cell line K562/ADM in vitro and explore the relationship between this effect and PI-3K/Akt signal transduction pathway.Methods After treated with different concentration of Sc,MTT method and clone formation test were used to determine the proliferative inhibition rate and survival rate of Sc on K562/ADM cell and the reversal index was calculated.The expression of phosphorylation Akt(p-Akt) was detected by Western Blot.Results K562/ADM cells had resistance to ADM.Meanwhile,after treatment with Sc,the inhibitory rates were significantly increased and the survival rates were significantly decreased in a dose and time dependent manner.Sc could obviously down-regulate the abundance of p-Akt(P0.01) and enhance the inhibitive effect of ADM on proliferation of K562/ADM cells(P0.05,P0.01),partly revealing the multidrug resistance of K562/ADM cell to ADM.Conclusion Selenium chitosan can inhibit the proliferation of K562/ADM cells and partly reverse the resistance to ADM,which is correlated with down-regulation of the PI-3K/Akt signal transduction pathway." @default.
- W2372384259 created "2016-06-24" @default.
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- W2372384259 date "2012-01-01" @default.
- W2372384259 modified "2023-09-23" @default.
- W2372384259 title "Correlation between Inhibitory Effect of Selenium chiston on K562/ADM Cells and PI-3K/Akt Signal Transduction Pathway" @default.
- W2372384259 hasPublicationYear "2012" @default.
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