Matches in SemOpenAlex for { <https://semopenalex.org/work/W2372728521> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2372728521 abstract "Objective In the present study,a model of cultured neonatal rat cardiomyocytes was established to observe the influence of fentanyl on the anoxic reoxygenation injury,and to investigate whether the direct action of fentany at the level of the neonatal rat cardiomyocytes could induce the preconditioning-like effect.Therefore,it would provide evidence,at the level of the myocytes,for the utilization of a large dose of fentanyl in the clinical anesthesia for cardioprotection against the ischemic reperfusion injury.Methods Cardiomyocytes were cultured from the neonatal rat heart according to a routine procedure,and divided into four groups: The normal control group(C group) didn't receive any treatment,while the other groups including anoxia/reoxygenation group(A/R group),AP group and fentanyl group(F group) all received a 2-hour anoxia and 1-hour reoxygenation.Before the prolonged anoxia,AP group was subjected to a 20-min exposure to anoxia followed by a 20-min of reoxygenation,and F group was subjected to a 20-minute exposure to fentanyl(50 ng/ml) followed by a 10-minute drug-free period.The cellular livability(the value of OD),the apoptosis percentage and the intracellular ultrastructure of the cardiomyocytes were measured by MTT colorimetry,the flow cytometer and the transmission electron microscope respectively.Results The cellular livability of F group and AP group were significantly higher than A/R group,and the apoptosis percentage of F group and AP group were significantly lower than A/R group.The cellular ultrastructure of A/R group indicated the feature of apoptosis,and those of AP group and F group remained normally.The livability and the apoptosis percentage of the cardiomyocytes between F group and AP group had no statistical difference.Conclusions Fentanyl can protect the cardiomyocytes against anoxic reoxygenation injury,and its cardioprotective effect is similar to the effect of IPC." @default.
- W2372728521 created "2016-06-24" @default.
- W2372728521 creator A5043099269 @default.
- W2372728521 date "2009-01-01" @default.
- W2372728521 modified "2023-09-23" @default.
- W2372728521 title "The comparison of fentanyl and anoxic preconditioning on the anoxic reoxygenation injury of the neonatal rat cardiomyocytes" @default.
- W2372728521 hasPublicationYear "2009" @default.
- W2372728521 type Work @default.
- W2372728521 sameAs 2372728521 @default.
- W2372728521 citedByCount "0" @default.
- W2372728521 crossrefType "journal-article" @default.
- W2372728521 hasAuthorship W2372728521A5043099269 @default.
- W2372728521 hasConcept C126322002 @default.
- W2372728521 hasConcept C16685009 @default.
- W2372728521 hasConcept C190283241 @default.
- W2372728521 hasConcept C207200792 @default.
- W2372728521 hasConcept C2781072394 @default.
- W2372728521 hasConcept C42219234 @default.
- W2372728521 hasConcept C55493867 @default.
- W2372728521 hasConcept C71924100 @default.
- W2372728521 hasConcept C86803240 @default.
- W2372728521 hasConcept C98274493 @default.
- W2372728521 hasConceptScore W2372728521C126322002 @default.
- W2372728521 hasConceptScore W2372728521C16685009 @default.
- W2372728521 hasConceptScore W2372728521C190283241 @default.
- W2372728521 hasConceptScore W2372728521C207200792 @default.
- W2372728521 hasConceptScore W2372728521C2781072394 @default.
- W2372728521 hasConceptScore W2372728521C42219234 @default.
- W2372728521 hasConceptScore W2372728521C55493867 @default.
- W2372728521 hasConceptScore W2372728521C71924100 @default.
- W2372728521 hasConceptScore W2372728521C86803240 @default.
- W2372728521 hasConceptScore W2372728521C98274493 @default.
- W2372728521 hasLocation W23727285211 @default.
- W2372728521 hasOpenAccess W2372728521 @default.
- W2372728521 hasPrimaryLocation W23727285211 @default.
- W2372728521 hasRelatedWork W2099388741 @default.
- W2372728521 hasRelatedWork W2359657844 @default.
- W2372728521 hasRelatedWork W2389765244 @default.
- W2372728521 hasRelatedWork W2571626338 @default.
- W2372728521 hasRelatedWork W2576134095 @default.
- W2372728521 hasRelatedWork W2588422344 @default.
- W2372728521 hasRelatedWork W2589011554 @default.
- W2372728521 hasRelatedWork W2977987419 @default.
- W2372728521 hasRelatedWork W3028851989 @default.
- W2372728521 hasRelatedWork W3029385295 @default.
- W2372728521 hasRelatedWork W3029904057 @default.
- W2372728521 hasRelatedWork W3030682033 @default.
- W2372728521 hasRelatedWork W3030853161 @default.
- W2372728521 hasRelatedWork W3031550858 @default.
- W2372728521 hasRelatedWork W3031677556 @default.
- W2372728521 hasRelatedWork W3031725373 @default.
- W2372728521 hasRelatedWork W3031831782 @default.
- W2372728521 hasRelatedWork W3031998087 @default.
- W2372728521 hasRelatedWork W3032628864 @default.
- W2372728521 hasRelatedWork W3031744416 @default.
- W2372728521 isParatext "false" @default.
- W2372728521 isRetracted "false" @default.
- W2372728521 magId "2372728521" @default.
- W2372728521 workType "article" @default.