Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380331373> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2380331373 abstract "Chronic hepatitis C virus(HCV)infection is one of global public health problems,and predominantly results in severe hepatic diseases including hepatic cirrhosis and hepatocellular carcinoma. The traditional standard of care for chronic HCV is the combination of ribavirin and pegylated interferon,which is insufficient to cure the HCV infection due to the suboptimal sustained viral response and severe side effects. Recently new therapeutic approaches have been developed,including direct-acting antiviral agents(DAA)and host-targeting agents,which target essential proteins or host factors in HCV life cycle,such as NS3/4A protease,NS5 B polymerase and NS5 A protein. These agents exhibit high efficacy,improving safety and tolerability. Thus,the approval of the nucleotide polymerase inhibitor sofosbuvir provides a breakthrough therapy against chronic hepatitis C infection. This review describes the current different classes of HCV inhibitors during the last decades,and their chemical structures,mechanisms and related antiviral property." @default.
- W2380331373 created "2016-06-24" @default.
- W2380331373 creator A5018244700 @default.
- W2380331373 date "2015-01-01" @default.
- W2380331373 modified "2023-09-26" @default.
- W2380331373 title "Anti-hepatitis C virus drugs:research advances" @default.
- W2380331373 hasPublicationYear "2015" @default.
- W2380331373 type Work @default.
- W2380331373 sameAs 2380331373 @default.
- W2380331373 citedByCount "0" @default.
- W2380331373 crossrefType "journal-article" @default.
- W2380331373 hasAuthorship W2380331373A5018244700 @default.
- W2380331373 hasConcept C126322002 @default.
- W2380331373 hasConcept C132379496 @default.
- W2380331373 hasConcept C142462285 @default.
- W2380331373 hasConcept C159047783 @default.
- W2380331373 hasConcept C197934379 @default.
- W2380331373 hasConcept C203014093 @default.
- W2380331373 hasConcept C2522874641 @default.
- W2380331373 hasConcept C2776408679 @default.
- W2380331373 hasConcept C2776455275 @default.
- W2380331373 hasConcept C2776461080 @default.
- W2380331373 hasConcept C2777214474 @default.
- W2380331373 hasConcept C2778019345 @default.
- W2380331373 hasConcept C2778375690 @default.
- W2380331373 hasConcept C2778390639 @default.
- W2380331373 hasConcept C2780040827 @default.
- W2380331373 hasConcept C2781143361 @default.
- W2380331373 hasConcept C2993143319 @default.
- W2380331373 hasConcept C3019392825 @default.
- W2380331373 hasConcept C71924100 @default.
- W2380331373 hasConcept C8891405 @default.
- W2380331373 hasConcept C98274493 @default.
- W2380331373 hasConceptScore W2380331373C126322002 @default.
- W2380331373 hasConceptScore W2380331373C132379496 @default.
- W2380331373 hasConceptScore W2380331373C142462285 @default.
- W2380331373 hasConceptScore W2380331373C159047783 @default.
- W2380331373 hasConceptScore W2380331373C197934379 @default.
- W2380331373 hasConceptScore W2380331373C203014093 @default.
- W2380331373 hasConceptScore W2380331373C2522874641 @default.
- W2380331373 hasConceptScore W2380331373C2776408679 @default.
- W2380331373 hasConceptScore W2380331373C2776455275 @default.
- W2380331373 hasConceptScore W2380331373C2776461080 @default.
- W2380331373 hasConceptScore W2380331373C2777214474 @default.
- W2380331373 hasConceptScore W2380331373C2778019345 @default.
- W2380331373 hasConceptScore W2380331373C2778375690 @default.
- W2380331373 hasConceptScore W2380331373C2778390639 @default.
- W2380331373 hasConceptScore W2380331373C2780040827 @default.
- W2380331373 hasConceptScore W2380331373C2781143361 @default.
- W2380331373 hasConceptScore W2380331373C2993143319 @default.
- W2380331373 hasConceptScore W2380331373C3019392825 @default.
- W2380331373 hasConceptScore W2380331373C71924100 @default.
- W2380331373 hasConceptScore W2380331373C8891405 @default.
- W2380331373 hasConceptScore W2380331373C98274493 @default.
- W2380331373 hasLocation W23803313731 @default.
- W2380331373 hasOpenAccess W2380331373 @default.
- W2380331373 hasPrimaryLocation W23803313731 @default.
- W2380331373 hasRelatedWork W1759010935 @default.
- W2380331373 hasRelatedWork W185667574 @default.
- W2380331373 hasRelatedWork W1968542811 @default.
- W2380331373 hasRelatedWork W1975576681 @default.
- W2380331373 hasRelatedWork W1977139658 @default.
- W2380331373 hasRelatedWork W1983560434 @default.
- W2380331373 hasRelatedWork W1997076006 @default.
- W2380331373 hasRelatedWork W2015216410 @default.
- W2380331373 hasRelatedWork W2016961740 @default.
- W2380331373 hasRelatedWork W2038269603 @default.
- W2380331373 hasRelatedWork W2135686790 @default.
- W2380331373 hasRelatedWork W2168673653 @default.
- W2380331373 hasRelatedWork W2214878929 @default.
- W2380331373 hasRelatedWork W2354506518 @default.
- W2380331373 hasRelatedWork W2385547651 @default.
- W2380331373 hasRelatedWork W2399390015 @default.
- W2380331373 hasRelatedWork W2419341966 @default.
- W2380331373 hasRelatedWork W2906947831 @default.
- W2380331373 hasRelatedWork W3023771755 @default.
- W2380331373 hasRelatedWork W3029033760 @default.
- W2380331373 isParatext "false" @default.
- W2380331373 isRetracted "false" @default.
- W2380331373 magId "2380331373" @default.
- W2380331373 workType "article" @default.