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- W2382321917 abstract "Objective To investigate the effects of smad7 on transdifferentiation and collagenⅠsynthesis in advanced glyeosylation end-products(AGE)-stimulated NRK52E cells.Methods NRK52E cells were transferred by pTet-on plasmid system and the cell lines of doxycycline(Dox)-regulated Smad7 expression were selected for the study.Transnuclear location of p-Smad2/3 was examined with immunocytochemistry.The mRNA and protein expressions of Smad7,α-SMA,E-cadherin,collagenⅠwere detected with RT-PCR and Western blot. Results AGE-induced expressions of Smad7 mRNA and protein were further increased in NRK52E cells by the addition of Dox in a dose-dependent manner.Overexpression of Smad7 caused a marked inhibition of p-Smad2/3 transnuclear location at 30 min(68.3% vs 31.2%,P0.01)and 24 h(69.8% vs 28.7%,P0.01).Dox- induced overexpression of Smad7 inhibited AGE-inducedα-SMA and eollagenⅠsynthesis and up-regulated E- Cadherin mRNA and protein levels.Conclusion Overexpression of Smad7 can inhibit AGE-stimulated transdifferentiation and collagenⅠproduction in NRK52E cells." @default.
- W2382321917 created "2016-06-24" @default.
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- W2382321917 date "2007-01-01" @default.
- W2382321917 modified "2023-09-28" @default.
- W2382321917 title "Effects of Smad7 on transdifferentiation and collagen I synthesis in AGE-stimulated NRK52E cells" @default.
- W2382321917 hasPublicationYear "2007" @default.
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