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- W2384163336 abstract "AIM To observe the protective effects of apigenin,luteolin,chrysin,galangin,kaemp-ferol and baicalein present study is designed of six flavonoids with similar structure against hepatotoxicity in human L-02 cells and mouse primary hepatocytes,and explore the relationship between their structures and actions.METHODS The cultured human L-02 cells and mouse primary hepatocytes were treated with carbon tetrachloride(CC1_4,10mmol·L~(-1)),toosendanin(TSN,2μmol·L~(-1)),senecionine(SENE,25μmo·L~(-1)) and deoxycholic acid taurine(TDCA,500μmol·L~(-1)),respectively.The hepatotoxins were added after flavonoids(100μmol·L~(-1)) were preincubated with the cells for 15 min.MTT assay was used to detect the cell viability after the incubation for 48 h.RESULTS Four hepatotoxins could siginificantly reduce the cell viability (P0.01) compared with the control group.After the treatments,baicalein and kaempferol could increase the cell viability of hepatotoxins-treated hepatocytes(P0.01).However,other compounds had no protective effects against hepatotoxicity.CONCLUSION Baicalein and kaempferol could both significantly prevent these hepatotoxins-induced cytotoxicity in human L-02 cells and mouse primary hepatocytes,however,apigenin, luteolin,chrysin and galangin failed to do so." @default.
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- W2384163336 date "2011-01-01" @default.
- W2384163336 modified "2023-09-28" @default.
- W2384163336 title "Comparison in protective effects of six flavonoids against hepatotoxins-induced cytotoxicity" @default.
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