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- W2389255737 abstract "Objective] This study is to investigate the potential effects on germ cells of male mice exposed to acrylonitrile.[Methods] The rats were given by ip acrylonitrile for 5 days at doses of 0,2 5,5,10mg/kg b.w.to observe the frequencies of micronuclei in early spermatogenic cells after 2 weeks,and by gavage at doses of 0,6,12,24mg/kg b.w.to analyze the rates of abnormal sperms.[Results] The frequencies of micronuclei in early spermatogenic cells were significantly increased at dose≥5 0mg/kg b.w.and there was a distinct dose response relationship ( y=0 270x 0 816,r =0 988).The numbers of abnormal sperms in the epididymis significantly increased at doses of 12 and 24mg/kg b.w.compared with those in control group in the second week after treatment,in 12mg/kg and 24mg/kg groups abnormal sperms highly increased in the fifth week after treatment ( P 0.01).These abnormalities were characterized by sperm heads without a hook or with a blunt hook.[Conclusion] Acrylonitrile could have the mutagenic effect on germ cells and cause increase in numbers of abnormal sperms,so it may affect reproductive function in male mice." @default.
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- W2389255737 date "2000-01-01" @default.
- W2389255737 modified "2023-09-24" @default.
- W2389255737 title "The Toxicity of Acrylonitrile to Germ Cells in ICR Male Mice" @default.
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