Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391385222> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2391385222 endingPage "9" @default.
- W2391385222 startingPage "907" @default.
- W2391385222 abstract "To observe the polymorphism of metabolizing enzyme N-actyltransferase 2 gene in populations with history of colorectal adenoma and polyp and to explore the relationship between NAT2 gene phenotype and colorectal cancer genetic susceptibility.A cohort of 4,076 patients with history of colorectal adenoma or polyp was established Fifty-two cases were randomly selected from those with recurrence more than 2 times during the twenty years' follow-up. Fifty-two without recurrence were randomly selected as controls. DNA was isolated from the lymphocytes of peripheral blood of these 104 subjects. NAT2 polymorphism was detected by PCR-RFLP.The frequency of wild-type NAT2 (Wt/Wt) was significantly higher in control group (17/52, 32.7%) than in recurrence group (8/52, 15.4%) (P < 0.05). The frequency of heterogeneity type of NAT2 was significantly higher in recurrence group (40/52, 76.9%) than in control group (30/52, 57.7%) (P < 0.05). If OR of wild-type NAT2 (Wt/Wt) was 1, OR of Wt/M* genotype was 2.96 (95% CI: 1.091-8.009), and OR of M*/M* genotype was 2.125 (95% CI: 0.666-6.781). There was no difference of distribution between rapid enzyme type and slow enzyme type in the two groups.The frequency of wild-type NAT2 gene (Wt/Wt) is significantly higher in patients without recurrence of adenoma or polyp than in patients with recurrence. The frequency of heterogeneity genotype of NAT2 is significantly higher in patients with recurrence of adenoma or polyp than in those without recurrence. Wild-genotype (Wt/Wt) may be a protection factor in recurrence of colorectal adenomas. No difference can be seen between the distribution of rapid and slow enzyme types in these two groups." @default.
- W2391385222 created "2016-06-24" @default.
- W2391385222 creator A5036224693 @default.
- W2391385222 creator A5086418698 @default.
- W2391385222 creator A5091643392 @default.
- W2391385222 date "2001-08-10" @default.
- W2391385222 modified "2023-09-23" @default.
- W2391385222 title "[N-actyltransferase2 polymorphism in recurrence of colorectal polyps and adenomas]." @default.
- W2391385222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11702663" @default.
- W2391385222 hasPublicationYear "2001" @default.
- W2391385222 type Work @default.
- W2391385222 sameAs 2391385222 @default.
- W2391385222 citedByCount "0" @default.
- W2391385222 crossrefType "journal-article" @default.
- W2391385222 hasAuthorship W2391385222A5036224693 @default.
- W2391385222 hasAuthorship W2391385222A5086418698 @default.
- W2391385222 hasAuthorship W2391385222A5091643392 @default.
- W2391385222 hasConcept C104317684 @default.
- W2391385222 hasConcept C121608353 @default.
- W2391385222 hasConcept C126322002 @default.
- W2391385222 hasConcept C135763542 @default.
- W2391385222 hasConcept C149737253 @default.
- W2391385222 hasConcept C2776861080 @default.
- W2391385222 hasConcept C2777428134 @default.
- W2391385222 hasConcept C526805850 @default.
- W2391385222 hasConcept C54355233 @default.
- W2391385222 hasConcept C71924100 @default.
- W2391385222 hasConcept C86803240 @default.
- W2391385222 hasConcept C90924648 @default.
- W2391385222 hasConceptScore W2391385222C104317684 @default.
- W2391385222 hasConceptScore W2391385222C121608353 @default.
- W2391385222 hasConceptScore W2391385222C126322002 @default.
- W2391385222 hasConceptScore W2391385222C135763542 @default.
- W2391385222 hasConceptScore W2391385222C149737253 @default.
- W2391385222 hasConceptScore W2391385222C2776861080 @default.
- W2391385222 hasConceptScore W2391385222C2777428134 @default.
- W2391385222 hasConceptScore W2391385222C526805850 @default.
- W2391385222 hasConceptScore W2391385222C54355233 @default.
- W2391385222 hasConceptScore W2391385222C71924100 @default.
- W2391385222 hasConceptScore W2391385222C86803240 @default.
- W2391385222 hasConceptScore W2391385222C90924648 @default.
- W2391385222 hasIssue "15" @default.
- W2391385222 hasLocation W23913852221 @default.
- W2391385222 hasOpenAccess W2391385222 @default.
- W2391385222 hasPrimaryLocation W23913852221 @default.
- W2391385222 hasRelatedWork W1968942241 @default.
- W2391385222 hasRelatedWork W1976714062 @default.
- W2391385222 hasRelatedWork W2003148646 @default.
- W2391385222 hasRelatedWork W2155078208 @default.
- W2391385222 hasRelatedWork W2161252404 @default.
- W2391385222 hasRelatedWork W2347824894 @default.
- W2391385222 hasRelatedWork W2355181271 @default.
- W2391385222 hasRelatedWork W2998988187 @default.
- W2391385222 hasRelatedWork W3012026232 @default.
- W2391385222 hasRelatedWork W2784843214 @default.
- W2391385222 hasVolume "81" @default.
- W2391385222 isParatext "false" @default.
- W2391385222 isRetracted "false" @default.
- W2391385222 magId "2391385222" @default.
- W2391385222 workType "article" @default.