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- W2393591511 abstract "AIM: To explore the effect of retinoid X receptor(RXR) agonists on high-glucose-induced proliferation of rat aortic smooth muscle cells(RASMCs).METHODS: RASMCs were cultured in DMEM containing glucose at normal concentration(5.5 mmol/L).For high glucose treatment,glucose solution was added up to a final concentration of 25 mmol/L.The proliferation of RASMCs was detected by WST-1 assay.DNA synthesis was measured by the method of BrdU incorporation.Cell cycle progression was determined by flow cytometry.Phosphorylated protein kinase C(PKC) and the expression levels of cyclin-dependent kinase 2(CDK2) and p27Kip1 were detected by immunoblotting.RESULTS: High glucose increased DNA synthesis,cell cycle progression,the expression of CDK2 and the proliferation of RASMCs.Meanwhile,the expression of p27Kip1 was decreased by high glucose.Treatment of RASMCs with RXR natural ligand 9-cis-retinoic acid(9-cis-RA) resulted in significant inhibition of high-glucose-induced proliferation,DNA synthesis,cell cycle progression and the expression of CDK2 in a concentration-dependent manner.9-cis-RA also reversed the effect of high glucose on the expression of p27Kip1.RXR specific ligand SR11237 demonstrated the same effect as the effect of 9-cis-RA at the same concentration.PKC inhibitor showed the similar effect on high-glucose-induced proliferation and the expression of CDK2 and p27Kip1 as the RXR agonists did.Furthermore,9-cis-RA and SR11237 rapidly inhibited high-glucose-induced activation of PKC.CONCLUSION: PKC is involved in high-glucose-induced proliferation of RASMCs.RXR agonists inhibit high-glucose-induced proliferation by depressing PKC activation in vascular smooth muscle cells." @default.
- W2393591511 created "2016-06-24" @default.
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- W2393591511 date "2013-01-01" @default.
- W2393591511 modified "2023-09-26" @default.
- W2393591511 title "Retinoid X receptor agonists antagonize high-glucose-induced proliferation of rat vascular smooth muscle cells by inactivation of protein kinase C" @default.
- W2393591511 hasPublicationYear "2013" @default.
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