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- W2393596019 abstract "[Objective] To observe the effects of pyrro1idine dithiocarbamate(PDTC),an inhibitor of NF—κB,on the growth of mouse Hca-F cell in vitro and in vivo.[Methods] Hca-F cells were cultured in complete medium containing PDTC in vitro.MTT assay was used to detect the inhibition of growth of Hca-F cell.In vivo,the mice were inoculated with Hca-F cells and divided randomly into two groups: mice of challenge control group were injected with normal saline,while those of PDTC treatment group were injected with PDTC solution.The volume of tumor and body weight of mice were measured every day.Mice were killed on day 10 after treatment.Malondialchehyche(MDA) content of tumor tissue was assayed with MDA reagent kit and TNF-content was assayed with RIA.[Results] PDTC inhibited the proliferation of Hca-F cells in vitro,the proliferation inhibition rate was 85.4% on concentration 25 μg/mL.In vivo,differences in the volume,weight of tumor,content of MDA and TNF-α level of tumor tissue supernant between the two groups were not significant(P0.05).[Conclusion] PDTC can inhibit the proliferation of Hca-F cell in vitro." @default.
- W2393596019 created "2016-06-24" @default.
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- W2393596019 date "2011-01-01" @default.
- W2393596019 modified "2023-09-24" @default.
- W2393596019 title "Role of PDTC in regulating the growth of mouse Hca-F cell" @default.
- W2393596019 hasPublicationYear "2011" @default.
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