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- W2393889808 abstract "Objective To improve the understanding of the diagnosis and treatment of hepatic veno-occlusive disease(HVOD) by analyzing the clinical features of HVOD caused by gynura root.Methods The clinical data of 102 cases of HVOD caused by gynura root reported from January 1980 to December 2009 in China was analyzed retrospectivelyand the related literatures were reviewed.Results Gynura root was dosed from 150 g to 5000 g(median 500g),lasted for over 4 days to 1 year(median 30 days).The main symptoms were abdominal distention(99%),abdominal pain(69.9%),hepatomegaly(93.5%),ascites(97.7%) and jaundice(63.5%).Liver function may be abnormal.The imaging features were unclear hepatic vein,flat posterohepatic vena cava but no obstruction in it by type-B ultrasonography(US),slow flow or reflux of portal vein by Doppler US and that contrast agent accumulated unevenly in parenchyma of liver in both portal period and lag period by CT contrast enhancement.The characteristic histological changes included hepatic congestion,sinusoidal dilatation,venous outflow occlusion,hepatocyte necrosis and endothelial oedema or fibrosis of centrilobular vein.After medical treatment,about 69.7% of 89 cases saw improvement,30.3% of them didn't recover,and other 13 cases were unknown.And there was significant effect in patients who were treated with anticoagulant(81.0%) compared with those without anticoagulant(47.8%)(P=0.002).Conclusion Gynura root is an important cause of HVOD.Early diagnosis and therapy with anticoagulant may be valuable to improve prognosis." @default.
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- W2393889808 date "2011-01-01" @default.
- W2393889808 modified "2023-09-24" @default.
- W2393889808 title "Clinical features of hepatic veno-occlusive disease induced by gynura root: analysis of 102 cases" @default.
- W2393889808 hasPublicationYear "2011" @default.
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