Matches in SemOpenAlex for { <https://semopenalex.org/work/W2395381100> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2395381100 endingPage "81" @default.
- W2395381100 startingPage "177" @default.
- W2395381100 abstract "Amrinone, a selective phosphodiesterase III inhibitor, has been developed as a nonglycoside, noncatecholamine agent with positive inotropic effect. In this study, we examined the effect of amrinone on human pulmonary arterial strips in vitro to understand its action on human pulmonary circulation. Amrinone (10(-5)-10(-3) g/ml) caused dose-dependent relaxation of human pulmonary arterial strips precontracted with 60 mM KCl. Preincubation with either meclofenamate (3.1 microM), a cyclooxygenase inhibitor, or L-N(G)-nitroarginine (100 microM), a competitive inhibitor of EDRF/NO, failed to inhibit amrinone-induced pulmonary vasodilation. The cyclic AMP (cAMP) levels in the supernatant of the lung vessel homogenates increased after incubation with amrinone (10(-3) g/ml). These findings indicate that amrinone causes vasodilation of human pulmonary artery in vitro, and suggest a possible role for cAMP in the mechanisms of amrinone-induced pulmonary vasodilation. Because it is suggested that amrinone has not only positive inotropic effect but also pulmonary vasodilative effect in human in this study, we speculate that amrinone could be an useful agent for the treatment of an increase in right heart afterload and consequent pulmonary hypertension and right heart failure after lung resection in human." @default.
- W2395381100 created "2016-06-24" @default.
- W2395381100 creator A5003932609 @default.
- W2395381100 creator A5012454543 @default.
- W2395381100 creator A5043495757 @default.
- W2395381100 creator A5054299347 @default.
- W2395381100 creator A5057421411 @default.
- W2395381100 creator A5071191264 @default.
- W2395381100 creator A5084738398 @default.
- W2395381100 date "1996-04-01" @default.
- W2395381100 modified "2023-09-23" @default.
- W2395381100 title "Relaxation of human isolated pulmonary arteries by amrinone." @default.
- W2395381100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8675527" @default.
- W2395381100 hasPublicationYear "1996" @default.
- W2395381100 type Work @default.
- W2395381100 sameAs 2395381100 @default.
- W2395381100 citedByCount "3" @default.
- W2395381100 countsByYear W23953811002019 @default.
- W2395381100 crossrefType "journal-article" @default.
- W2395381100 hasAuthorship W2395381100A5003932609 @default.
- W2395381100 hasAuthorship W2395381100A5012454543 @default.
- W2395381100 hasAuthorship W2395381100A5043495757 @default.
- W2395381100 hasAuthorship W2395381100A5054299347 @default.
- W2395381100 hasAuthorship W2395381100A5057421411 @default.
- W2395381100 hasAuthorship W2395381100A5071191264 @default.
- W2395381100 hasAuthorship W2395381100A5084738398 @default.
- W2395381100 hasConcept C120770815 @default.
- W2395381100 hasConcept C126322002 @default.
- W2395381100 hasConcept C155710745 @default.
- W2395381100 hasConcept C164705383 @default.
- W2395381100 hasConcept C2776766087 @default.
- W2395381100 hasConcept C2779739782 @default.
- W2395381100 hasConcept C2780940725 @default.
- W2395381100 hasConcept C42219234 @default.
- W2395381100 hasConcept C71924100 @default.
- W2395381100 hasConceptScore W2395381100C120770815 @default.
- W2395381100 hasConceptScore W2395381100C126322002 @default.
- W2395381100 hasConceptScore W2395381100C155710745 @default.
- W2395381100 hasConceptScore W2395381100C164705383 @default.
- W2395381100 hasConceptScore W2395381100C2776766087 @default.
- W2395381100 hasConceptScore W2395381100C2779739782 @default.
- W2395381100 hasConceptScore W2395381100C2780940725 @default.
- W2395381100 hasConceptScore W2395381100C42219234 @default.
- W2395381100 hasConceptScore W2395381100C71924100 @default.
- W2395381100 hasIssue "2" @default.
- W2395381100 hasLocation W23953811001 @default.
- W2395381100 hasOpenAccess W2395381100 @default.
- W2395381100 hasPrimaryLocation W23953811001 @default.
- W2395381100 hasRelatedWork W1987949657 @default.
- W2395381100 hasRelatedWork W2010319098 @default.
- W2395381100 hasRelatedWork W2029961393 @default.
- W2395381100 hasRelatedWork W2036219284 @default.
- W2395381100 hasRelatedWork W2048737544 @default.
- W2395381100 hasRelatedWork W2061207631 @default.
- W2395381100 hasRelatedWork W2076331410 @default.
- W2395381100 hasRelatedWork W2080958097 @default.
- W2395381100 hasRelatedWork W2087795581 @default.
- W2395381100 hasRelatedWork W2397985650 @default.
- W2395381100 hasVolume "37" @default.
- W2395381100 isParatext "false" @default.
- W2395381100 isRetracted "false" @default.
- W2395381100 magId "2395381100" @default.
- W2395381100 workType "article" @default.