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- W2398564722 abstract "Mitochondria actively contribute to apoptotic cell death through mechanisms including the loss of integrity of the outer mitochondrial membrane, the release of intermembrane space proteins, such as cytochrome c, in the cytosol and the caspase cascade activation. This process is the result of careful cooperation not only among members of the Bcl-2 family but also dynamin-related proteins. These events are often accompanied by fission of the organelle, thus linking mitochondrial dynamics to apoptosis. Emerging evidences are suggesting a fine regulation of mitochondrial morphology by Bcl-2 family members and active participation of fission-fusion proteins in apoptosis. The debate whether in mitochondrial morphogenesis the role of Bcl-2 family members is functionally distinct from their role in apoptosis is still open and, above all, which morphological changes are associated with cell death sensitisation. This review will cover the findings on how the mitochondrial fission and fusion machinery may intersect apoptotic pathways focusing on recent advances on the key role played by Mcl-1." @default.
- W2398564722 created "2016-06-24" @default.
- W2398564722 creator A5007424526 @default.
- W2398564722 creator A5013940165 @default.
- W2398564722 creator A5024277943 @default.
- W2398564722 creator A5070894673 @default.
- W2398564722 creator A5084497657 @default.
- W2398564722 creator A5086468991 @default.
- W2398564722 date "2016-10-01" @default.
- W2398564722 modified "2023-10-17" @default.
- W2398564722 title "Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1" @default.
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