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• W2407457321 abstract "No AccessJournal of Urology1 Jun 1994The Effect of Allopurinol Pretreatment Before Detorting Testicular Torsion Feza M. Akgür, Kamer Kilinç, Tanju Aktuǧ, and Mustafa Olguner Feza M. AkgürFeza M. Akgür More articles by this author , Kamer KilinçKamer Kilinç More articles by this author , Tanju AktuǧTanju Aktuǧ More articles by this author , and Mustafa OlgunerMustafa Olguner More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35351-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The resumption of blood flow to organs following ischemia may cause a further increase in tissue damage through an increase in peroxidation of lipids in cell membranes. An experimental study was conducted to investigate the prevention of reperfusion injury after testicular torsion through changes in the lipid peroxide content of the testis. Adult male albino rats were divided into 11 groups, each containing 10 rats. One group served to determine base values of the lipid peroxide content of the testis and kidney; 3 groups were subjected to unilateral testicular torsion lasting 1, 3 and 5 hours; 3 groups were subjected to detorsion following torsion lasting 1, 3 and 5 hours; 3 groups were treated with allopurinol before detorsion following torsion lasting 1, 3 and 5 hours; and 1 group underwent sham operation as a control. Thiobarbituric acid reactive products of lipid peroxidation (TEAR) were assessed in testicular and renal tissues. Testicular torsion caused a significant increase in TEAR in the testis (p < 0.01), but not in the kidneys. Detorsion caused a further significant increase in testicular TEAR (p < 0.01). Pretreatment with allopurinol prevented this further increase (p < 0.01). It is concluded that, biochemically, reperfusion injury occurs in the testis following detorsion after testicular torsion of 720° lasting as long as 5 hours. Pretreatment with allopurinol before detorsion prevents such reperfusion injury. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByKEHINDE E, MOJIMINIYI O, MAHMOUD A, AL-AWADI K, AL-HUNAYAN A and OMU A (2018) The Significance of Measuring the Time Course of Serum Malondialdehyde Concentration in Patients With Torsion of the TestisJournal of Urology, VOL. 169, NO. 6, (2177-2180), Online publication date: 1-Jun-2003.BOZLU M, ESKANDARİ G, ÇAYAN S, CANPOLAT B, AKBAY E and ATİK U (2018) The Effect of Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors on Biochemical Changes in Testicular Ischemia-Reperfusion InjuryJournal of Urology, VOL. 169, NO. 5, (1870-1873), Online publication date: 1-May-2003.Prillaman H and Turner T (2018) Rescue of Testicular Function After Acute Experimental TorsionJournal of Urology, VOL. 157, NO. 1, (340-345), Online publication date: 1-Jan-1997. Volume 151Issue 6June 1994Page: 1715-1717 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordstestisreperfusion injurytorsionfree radicalsMetricsAuthor Information Feza M. Akgür More articles by this author Kamer Kilinç More articles by this author Tanju Aktuǧ More articles by this author Mustafa Olguner More articles by this author Expand All Advertisement Loading ..." @default.
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• W2407457321 title "The Effect of Allopurinol Pretreatment Before Detorting Testicular Torsion" @default.
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