FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462271882> ?p ?o ?g. }

• W2462271882 endingPage "762" @default.
• W2462271882 startingPage "751" @default.
• W2462271882 abstract "Rationale Targeted oxidized fatty acid analysis has been widely used to understand the roles of fatty acids in the development of diseases. However, because of the extensive structural diversity of fatty acids, it is considered that unknown lipid metabolites will remain undetected. Here, to discover and identify unknown lipid metabolites in biological samples, a global analytical system and a method of synthesizing lipid standards were investigated. Methods Oxidized fatty acids in mouse lung tissues were extracted using mixed‐mode spin columns. Separation was achieved via ultra‐high‐performance liquid chromatography, mass spectrometric (MS) analysis was conducted in full scan mode using a Q Exactive Plus instrument equipped with an electrospray ionization probe, and structure analysis was carried out by high‐resolution data‐dependent tandem mass spectrometry (dd‐MS 2 ). In addition, lipid standards, which are not commercially available, were synthesized by bioconversion using Bacillus circulans . Results Oxidized fatty acids in mouse lung tissues were analyzed by high‐resolution accurate‐mass analysis, and multiple unknown molecules were discovered and tentatively identified using high‐resolution dd‐MS 2 . Among these molecules, 21‐hydroxydocosahexaenoic acid (21‐HDoHE) and 22‐HDoHE, which are not commercially available, were synthesized by bioconversion. By comparing the exact masses, retention times, and characteristic fragment ions of the synthesized standards, 21‐HDoHE and 22‐HDoHE were definitively identified in the mouse lung tissue. Conclusions Our strategy of global analysis and bioconversion can be used for the discovery and identification of unknown lipid molecules. Copyright © 2016 John Wiley & Sons, Ltd." @default.
• W2462271882 created "2016-07-22" @default.
• W2462271882 creator A5010338083 @default.
• W2462271882 creator A5044707863 @default.
• W2462271882 creator A5049214417 @default.
• W2462271882 creator A5051304038 @default.
• W2462271882 creator A5054162835 @default.
• W2462271882 creator A5058865333 @default.
• W2462271882 creator A5062147748 @default.
• W2462271882 creator A5072188667 @default.
• W2462271882 creator A5078829609 @default.
• W2462271882 date "2016-02-09" @default.
• W2462271882 modified "2023-10-16" @default.
• W2462271882 title "A hybrid strategy using global analysis of oxidized fatty acids and bioconversion by<i>Bacillus circulans</i>" @default.
• W2462271882 cites W1641198271 @default.
• W2462271882 cites W1857256453 @default.
• W2462271882 cites W1970668209 @default.
• W2462271882 cites W1972262472 @default.
• W2462271882 cites W1981926613 @default.
• W2462271882 cites W1982555544 @default.
• W2462271882 cites W1984238073 @default.
• W2462271882 cites W1985058290 @default.
• W2462271882 cites W1994759965 @default.
• W2462271882 cites W1999682234 @default.
• W2462271882 cites W2002455578 @default.
• W2462271882 cites W2010202106 @default.
• W2462271882 cites W2012966224 @default.
• W2462271882 cites W2020366011 @default.
• W2462271882 cites W2029607642 @default.
• W2462271882 cites W2033610858 @default.
• W2462271882 cites W2038222125 @default.
• W2462271882 cites W2039850229 @default.
• W2462271882 cites W2045144594 @default.
• W2462271882 cites W2051818206 @default.
• W2462271882 cites W2056240857 @default.
• W2462271882 cites W2057050975 @default.
• W2462271882 cites W2065295548 @default.
• W2462271882 cites W2074262094 @default.
• W2462271882 cites W2076730930 @default.
• W2462271882 cites W2079501596 @default.
• W2462271882 cites W2079585822 @default.
• W2462271882 cites W2090609282 @default.
• W2462271882 cites W2091423693 @default.
• W2462271882 cites W2095236039 @default.
• W2462271882 cites W2100986426 @default.
• W2462271882 cites W2101037156 @default.
• W2462271882 cites W2110523555 @default.
• W2462271882 cites W2114991147 @default.
• W2462271882 cites W2119001453 @default.
• W2462271882 cites W2122405246 @default.
• W2462271882 cites W2148089123 @default.
• W2462271882 cites W2149511713 @default.
• W2462271882 cites W2157240187 @default.
• W2462271882 cites W2165082991 @default.
• W2462271882 cites W2282862962 @default.
• W2462271882 cites W2324924100 @default.
• W2462271882 cites W2407464994 @default.
• W2462271882 cites W412403171 @default.
• W2462271882 doi "https://doi.org/10.1002/rcm.7504" @default.
• W2462271882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26864527" @default.
• W2462271882 hasPublicationYear "2016" @default.
• W2462271882 type Work @default.
• W2462271882 sameAs 2462271882 @default.
• W2462271882 citedByCount "6" @default.
• W2462271882 countsByYear W24622718822017 @default.
• W2462271882 countsByYear W24622718822018 @default.
• W2462271882 countsByYear W24622718822019 @default.
• W2462271882 countsByYear W24622718822020 @default.
• W2462271882 countsByYear W24622718822022 @default.
• W2462271882 countsByYear W24622718822023 @default.
• W2462271882 crossrefType "journal-article" @default.
• W2462271882 hasAuthorship W2462271882A5010338083 @default.
• W2462271882 hasAuthorship W2462271882A5044707863 @default.
• W2462271882 hasAuthorship W2462271882A5049214417 @default.
• W2462271882 hasAuthorship W2462271882A5051304038 @default.
• W2462271882 hasAuthorship W2462271882A5054162835 @default.
• W2462271882 hasAuthorship W2462271882A5058865333 @default.
• W2462271882 hasAuthorship W2462271882A5062147748 @default.
• W2462271882 hasAuthorship W2462271882A5072188667 @default.
• W2462271882 hasAuthorship W2462271882A5078829609 @default.
• W2462271882 hasBestOaLocation W24622718821 @default.
• W2462271882 hasConcept C100544194 @default.
• W2462271882 hasConcept C138268822 @default.
• W2462271882 hasConcept C154945302 @default.
• W2462271882 hasConcept C162356407 @default.
• W2462271882 hasConcept C181199279 @default.
• W2462271882 hasConcept C185592680 @default.
• W2462271882 hasConcept C2776295094 @default.
• W2462271882 hasConcept C2780074830 @default.
• W2462271882 hasConcept C31827203 @default.
• W2462271882 hasConcept C40684141 @default.
• W2462271882 hasConcept C41008148 @default.
• W2462271882 hasConcept C43617362 @default.
• W2462271882 hasConcept C543025807 @default.
• W2462271882 hasConcept C55493867 @default.
• W2462271882 hasConceptScore W2462271882C100544194 @default.
• W2462271882 hasConceptScore W2462271882C138268822 @default.
• W2462271882 hasConceptScore W2462271882C154945302 @default.

• next