Matches in SemOpenAlex for { <https://semopenalex.org/work/W2480854865> ?p ?o ?g. }
- W2480854865 abstract "Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are further exacerbated by the metabolic syndrome. The duration of diabetes and glycemic control may have an impact on the type and severity of cognitive impairment, but as yet we cannot predict who is at greatest risk of developing cognitive impairment. The pathophysiology of cognitive impairment is multifactorial, although dysfunction in each interconnecting pathway ultimately leads to discordance in metabolic signaling. The pathophysiology includes defects in insulin signaling, autonomic function, neuroinflammatory pathways, mitochondrial (Mt) metabolism, the sirtuin-peroxisome proliferator-activated receptor-gamma co-activator 1α (SIRT-PGC-1α) axis, and Tau signaling. Several promising therapies have been identified in pre-clinical studies, but remain to be validated in clinical trials." @default.
- W2480854865 created "2016-08-23" @default.
- W2480854865 creator A5020879974 @default.
- W2480854865 creator A5029017464 @default.
- W2480854865 creator A5088804192 @default.
- W2480854865 creator A5089289614 @default.
- W2480854865 date "2016-08-04" @default.
- W2480854865 modified "2023-10-16" @default.
- W2480854865 title "Diabetes and Cognitive Impairment" @default.
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