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- W2485968247 abstract "Background: In situ formation of a coronary thrombus with subsequent spontaneous thrombolysis may explain the pathogenesis of Myocardial Infarction with Non-Obstructed Coronary Arteries (MINOCA). The objective of this study is to examine whether the risk of thrombosis is higher in MINOCA compared to myocardial infarct patients with coronary artery disease (MICAD) by assessing endogenous thrombin potential (ETP), congenital and acquired thrombophilia states. Methods: Twenty-four consecutive MINOCA patients (58±3 years, 50% women) and 24 age/gender-matched MICAD patients (60±3 years, 47% women) were prospectively recruited and samples obtained for propensity for tissue factor induced thrombin generation, as well as a thrombophilia screen panel at 1 month. Results: There was no difference between groups in thrombin generation indices, highlighting similar ETP between MINOCA and MICAD (1586 (1380,2000) vs. 1750 (1511,2042), p>0.05). Congenital thrombophilia states including decreased antithrombin (8% vs. 0%, p>0.05), protein C (0% vs. 0%), & protein S (4% vs. 0%, p>0.05), presence of factor V Leiden (0% vs. 4%, p>0.05), & prothrombin gene mutation (8% vs. 4%, p>0.05), and acquired thrombophilia states including anticardiolipin antibodies (0% vs 0%); lupus anticoagulant (0% vs. 0%), raised factor VIII (42% vs. 31%, p>0.05), & von willebrand factor (15% vs. 3%, p>0.05) were not significantly different between MINOCA and MICAD, respectively Conclusions: In this small pilot study, MINOCA patients did show abnormalities in thrombophilia states but these did not differ to those observed in MICAD. A larger study is required to evaluate this hypothesis." @default.
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- W2485968247 date "2016-08-01" @default.
- W2485968247 modified "2023-10-18" @default.
- W2485968247 title "Risk of Thrombosis in Myocardial Infarction with Non Obstructive Coronary Arteries (MINOCA)" @default.
- W2485968247 doi "https://doi.org/10.1016/j.hlc.2016.06.144" @default.
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