Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489359341> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W2489359341 endingPage "122" @default.
- W2489359341 startingPage "99" @default.
- W2489359341 abstract "Acute light-induced photoreceptor cell degeneration has been studied for over 35 years as a model of visual cell loss arising from genetic and age-related disease or light-induced trauma during ocular surgery. The rationale for these studies has been based largely on morphological similarities between the end stages of disease and the appearance of the retina after experimental retinal degenerations. While much has been learned, the recent advent of transgenic animal models of human disease and retinal gene knockouts has resulted in renewed interest in the light-damage model. In addition to using acute intense light to test the relevance of genetically modified animals as models of human retinal degenerations, we have also gained insights into the mechanism of retinal light damage. We now know that visual cell loss, whether of genetic origin, age-related, or light-induced, involves programmed cell death. We also know that light exposure induces an oxidative stress in the retina that may trigger apoptosis, leading to photoreceptor cell degeneration. Accordingly, genetic predisposition and environmental light appear to produce synergistic effects on the survival or demise of visual cells. The great advantage of acute light damage, however, is that if done correctly it can result in the synchronous involvement of numerous photoreceptors, whereas genetic or age-related degenerations involve fewer photoreceptors over much longer periods of time. Retinal light damage, therefore, provides an opportunityto study cell death during a shortened time course and to determine the order of events leading to retinal degeneration." @default.
- W2489359341 created "2016-08-23" @default.
- W2489359341 creator A5053863457 @default.
- W2489359341 creator A5069777316 @default.
- W2489359341 creator A5074091322 @default.
- W2489359341 date "2003-07-15" @default.
- W2489359341 modified "2023-10-16" @default.
- W2489359341 title "Light-Induced Retinal Degeneration" @default.
- W2489359341 cites W1967155965 @default.
- W2489359341 doi "https://doi.org/10.1201/b14822-9" @default.
- W2489359341 hasPublicationYear "2003" @default.
- W2489359341 type Work @default.
- W2489359341 sameAs 2489359341 @default.
- W2489359341 citedByCount "3" @default.
- W2489359341 countsByYear W24893593412014 @default.
- W2489359341 crossrefType "book-chapter" @default.
- W2489359341 hasAuthorship W2489359341A5053863457 @default.
- W2489359341 hasAuthorship W2489359341A5069777316 @default.
- W2489359341 hasAuthorship W2489359341A5074091322 @default.
- W2489359341 hasConcept C118487528 @default.
- W2489359341 hasConcept C2779354088 @default.
- W2489359341 hasConcept C2780827179 @default.
- W2489359341 hasConcept C2781040256 @default.
- W2489359341 hasConcept C71924100 @default.
- W2489359341 hasConceptScore W2489359341C118487528 @default.
- W2489359341 hasConceptScore W2489359341C2779354088 @default.
- W2489359341 hasConceptScore W2489359341C2780827179 @default.
- W2489359341 hasConceptScore W2489359341C2781040256 @default.
- W2489359341 hasConceptScore W2489359341C71924100 @default.
- W2489359341 hasLocation W24893593411 @default.
- W2489359341 hasOpenAccess W2489359341 @default.
- W2489359341 hasPrimaryLocation W24893593411 @default.
- W2489359341 hasRelatedWork W1977015089 @default.
- W2489359341 hasRelatedWork W2038436445 @default.
- W2489359341 hasRelatedWork W2063386043 @default.
- W2489359341 hasRelatedWork W2101007937 @default.
- W2489359341 hasRelatedWork W2410539798 @default.
- W2489359341 hasRelatedWork W2588576113 @default.
- W2489359341 hasRelatedWork W2918335976 @default.
- W2489359341 hasRelatedWork W2981660034 @default.
- W2489359341 hasRelatedWork W3030458811 @default.
- W2489359341 hasRelatedWork W4297619318 @default.
- W2489359341 isParatext "false" @default.
- W2489359341 isRetracted "false" @default.
- W2489359341 magId "2489359341" @default.
- W2489359341 workType "book-chapter" @default.