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- W24969790 abstract "Research on aminoglycoside antibiotics (AGAs) is still ongoing and the main interests are (1) the mechanisms of action on the bacterial ribosome; (2) biosynthesis and physiology of AGAs in their producers, (3) biochemistry and genetics of resistance determinants in both producers and clinically relevant bacteria, and (4) the recent molecular biological analysis of the biosynthetic potential of AGA producers. Our main focus will be on the aminocyclitol-containing AGAs (ACAGAs) and a summary of the genetics and biosynthetic pathways for the major classes thereof as well as a look at the future possibilities for understanding the biochemical and genetic evolution of ACAGAs and on using this knowledge for pathway engineering leading to new end products with improved therapeutic properties. We will concentrate on the ACAGAs binding to the 16S rRNA component of the small subunit (30S) of the bacterial ribosome. Also, a short account of the current situation resulting from resistance development against the major groups of therapeutically used ACAGAs will be given." @default.
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- W24969790 date "2009-01-01" @default.
- W24969790 modified "2023-10-14" @default.
- W24969790 title "Aminoglycosides, Bioactive Bacterial Metabolites" @default.
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- W24969790 doi "https://doi.org/10.1016/b978-012373944-5.00038-9" @default.
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