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• W2533083675 abstract "Introduction: The standard adjuvant therapy of patients with pancreatic carcinoma is gemcitabine. The role of vitamin C in prevention and therapy of different tumours was controversially discussed in the past. High serum levels of vitamin Ca re responsible for the protective effect in gastric carcinoma and also MMP-Inhibition was observed in the human pancreatic carcinoma cell line (MIAPaCa-2). This MMP-Inhibition leads to anti tumour effects. Aim of the study was to analyse the effect of gemcitabine and vitamin C in vitro with proliferation assays on BxPC-3 cells and HUVEC’s. Furthermore this was also analysed in vivo in a human pancreatic cancer mouse model (SCID). Methods: Human pancreatic cancer cell line (BxPC-3) was injected subcutaneously (s. c.) into the dorsa of male, immunodeficient (SCID) mice. When tumour volume was 100 mm 3 , mice were randomized into each six groups (n = 5–7/group) receiving gemcitabine twice a week 125 mg/kgKG i. p. (group 1). Vitamin C mono therapy every other day 23 mg/mouse i. p. (group 2), 2,3 mg/mouse i. p. (group 3) 0,23 mg/mouse i. p. (group 4). The combination group (group 5) was treated twice a week with gemcitabine 125 mg/kgKG i. p. and additionally thrice a week vitamin C 2,3 mg/kgKG i. p. The control group (group 6) was treated with placebo solution i. p. Tumour volume was measured every third day with a digital calliper. At the end of the experiment tumour sections were analysed according to the microvessel density (CD31), apoptosis (TUNEL) and proliferation (Ki-67). Furthermore in vitro the IC50 value of each compound and of the combination therapy was analysed on BxPC-3 cells and HUVEC’s. Non-parametric statistical analysis was performed. Results: Tumour inhibition rate (%) for BxPC-3 (slow growing tumour) was 48 % for group 1, 0 % for group 2, 8 % for group 3, 27 % for group 4 and 62 % for group 5. The inhibition of tumour growth was statistically significant in group 2a nd group 5c ompared with group 6 (p = 0,006). All mice gained weight throughout the study." @default.
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• W2533083675 date "2008-01-01" @default.
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• W2533083675 title "In vitro und in vivo Analyse der Wirkung von Vitamin C und Gemcitabine auf eine humane Pankreaskarzinom- Zelllinie (BxPC-3) sowie HUVEC's und die Tumorinhibition im Pankreaskarzinom SCID-Maus-Modell Analysis of in vitro and in vivo effectiveness of vitamin C and gemcitabine in human pancreatic carcinoma cell line (BxPC-3), human umbilical vein endothelial cells (HUVEC's) and tumour growth inhibition in a pancreas carcinoma SCID-mice model." @default.
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