Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534923078> ?p ?o ?g. }
- W2534923078 endingPage "77634" @default.
- W2534923078 startingPage "77622" @default.
- W2534923078 abstract "Bortezomib (BTZ), a proteasome inhibitor, is the first proteasome inhibitor to be used in clinical practice. Here we investigated the mechanisms underlying acquired bortezomib resistance in hepatocellular carcinoma (HCC) cells. Using stepwise selection, we established two acquired bortezomib-resistant HCC cell lines, a bortezomib-resistant HepG2 cell line (HepG2/BTZ) and bortezomib-resistant HuH7 cell line (HuH7/BTZ). The 50% inhibitory concentration values of HepG2/BTZ and HuH7/BTZ were respectively 15- and 39-fold higher than those of parental cell lines. Sequence analysis of the bortezomib-binding pocket in the β5-subunit showed no mutation. However, bortezomib-resistant HCC cells had increased expression of β1 and β5 proteasome subunits. These alterations of proteasome expression were accompanied by a weak degree of proteasome inhibition in bortezomib-resistant cells than that in wild-type cells after bortezomib exposure. Furthermore, bortezomib-resistant HCC cells acquired resistance to apoptosis. Bortezomib up-regulated pro-apoptotic proteins of the Bcl-2 protein family, Bax and Noxa in wild-type HCC cells. However, in bortezomib-resistant HCC cells, resistance to apoptosis was accompanied by loss of the ability to stabilize and accumulate these proteins. Thus, increased expression and increased activity of proteasomes constitute an adaptive and auto regulatory feedback mechanism to allow cells to survive exposure bortezomib." @default.
- W2534923078 created "2016-10-28" @default.
- W2534923078 creator A5010059969 @default.
- W2534923078 creator A5041381816 @default.
- W2534923078 creator A5082917975 @default.
- W2534923078 date "2016-10-18" @default.
- W2534923078 modified "2023-10-17" @default.
- W2534923078 title "Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance" @default.
- W2534923078 cites W1491514047 @default.
- W2534923078 cites W1600462418 @default.
- W2534923078 cites W1735420515 @default.
- W2534923078 cites W1878457905 @default.
- W2534923078 cites W1882566069 @default.
- W2534923078 cites W1906921637 @default.
- W2534923078 cites W1929371465 @default.
- W2534923078 cites W1963689482 @default.
- W2534923078 cites W1965790877 @default.
- W2534923078 cites W1970060716 @default.
- W2534923078 cites W1979280056 @default.
- W2534923078 cites W1984547206 @default.
- W2534923078 cites W1984998337 @default.
- W2534923078 cites W2010163650 @default.
- W2534923078 cites W2017937681 @default.
- W2534923078 cites W2018289835 @default.
- W2534923078 cites W2024846074 @default.
- W2534923078 cites W2024996523 @default.
- W2534923078 cites W2026043555 @default.
- W2534923078 cites W2039180923 @default.
- W2534923078 cites W2042850275 @default.
- W2534923078 cites W2053728180 @default.
- W2534923078 cites W2085459881 @default.
- W2534923078 cites W2086634576 @default.
- W2534923078 cites W2086676471 @default.
- W2534923078 cites W2087877138 @default.
- W2534923078 cites W2089865526 @default.
- W2534923078 cites W2099878195 @default.
- W2534923078 cites W2100424268 @default.
- W2534923078 cites W2100837269 @default.
- W2534923078 cites W2103637700 @default.
- W2534923078 cites W2104706142 @default.
- W2534923078 cites W2111810335 @default.
- W2534923078 cites W2112003796 @default.
- W2534923078 cites W2122684890 @default.
- W2534923078 cites W2124426490 @default.
- W2534923078 cites W2127358965 @default.
- W2534923078 cites W2127738863 @default.
- W2534923078 cites W2132485651 @default.
- W2534923078 cites W2134334757 @default.
- W2534923078 cites W2137052325 @default.
- W2534923078 cites W2144962084 @default.
- W2534923078 cites W2149843709 @default.
- W2534923078 cites W2153935627 @default.
- W2534923078 cites W2166987747 @default.
- W2534923078 cites W2176799918 @default.
- W2534923078 cites W2238856458 @default.
- W2534923078 cites W2253288561 @default.
- W2534923078 cites W2335735158 @default.
- W2534923078 cites W2460207510 @default.
- W2534923078 cites W4235337519 @default.
- W2534923078 doi "https://doi.org/10.18632/oncotarget.12731" @default.
- W2534923078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5363609" @default.
- W2534923078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27769058" @default.
- W2534923078 hasPublicationYear "2016" @default.
- W2534923078 type Work @default.
- W2534923078 sameAs 2534923078 @default.
- W2534923078 citedByCount "29" @default.
- W2534923078 countsByYear W25349230782017 @default.
- W2534923078 countsByYear W25349230782018 @default.
- W2534923078 countsByYear W25349230782019 @default.
- W2534923078 countsByYear W25349230782020 @default.
- W2534923078 countsByYear W25349230782021 @default.
- W2534923078 countsByYear W25349230782022 @default.
- W2534923078 countsByYear W25349230782023 @default.
- W2534923078 crossrefType "journal-article" @default.
- W2534923078 hasAuthorship W2534923078A5010059969 @default.
- W2534923078 hasAuthorship W2534923078A5041381816 @default.
- W2534923078 hasAuthorship W2534923078A5082917975 @default.
- W2534923078 hasBestOaLocation W25349230781 @default.
- W2534923078 hasConcept C185592680 @default.
- W2534923078 hasConcept C190283241 @default.
- W2534923078 hasConcept C203014093 @default.
- W2534923078 hasConcept C27740335 @default.
- W2534923078 hasConcept C2776364478 @default.
- W2534923078 hasConcept C2777478702 @default.
- W2534923078 hasConcept C2778367456 @default.
- W2534923078 hasConcept C502942594 @default.
- W2534923078 hasConcept C54355233 @default.
- W2534923078 hasConcept C55493867 @default.
- W2534923078 hasConcept C71924100 @default.
- W2534923078 hasConcept C81885089 @default.
- W2534923078 hasConcept C86803240 @default.
- W2534923078 hasConcept C95444343 @default.
- W2534923078 hasConcept C98274493 @default.
- W2534923078 hasConceptScore W2534923078C185592680 @default.
- W2534923078 hasConceptScore W2534923078C190283241 @default.
- W2534923078 hasConceptScore W2534923078C203014093 @default.
- W2534923078 hasConceptScore W2534923078C27740335 @default.
- W2534923078 hasConceptScore W2534923078C2776364478 @default.