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• W2537551187 abstract "During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-length, defined by RBC shape, is not a factor that could meaningfully compromise physiology. Here, we evaluated CO2 diffusivity (DCO2) in RBCs and related our results to cell shape. DCO2 inside RBCs was determined by fluorescence imaging of [H+] dynamics in cells under superfusion. This method is based on the principle that H+ diffusion is facilitated by CO2/HCO3- buffer and thus provides a read-out of DCO2. By imaging the spread of H+ ions from a photochemically-activated source (6-nitroveratraldehyde), DCO2 in human RBCs was calculated to be only 5% of the rate in water. Measurements on RBCs containing different hemoglobin concentrations demonstrated a halving of DCO2 with every 75 g/L increase in mean corpuscular hemoglobin concentration (MCHC). Thus, to compensate for highly-restricted cytoplasmic diffusion, RBC thickness must be reduced as appropriate for its MCHC. This can explain the inverse relationship between MCHC and RBC thickness determined from >250 animal species." @default.
• W2537551187 created "2016-10-28" @default.
• W2537551187 creator A5026204246 @default.
• W2537551187 creator A5048782870 @default.
• W2537551187 date "2016-10-25" @default.
• W2537551187 modified "2023-10-13" @default.
• W2537551187 title "Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm" @default.
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• W2537551187 doi "https://doi.org/10.1038/srep36018" @default.
• W2537551187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5078773" @default.
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• W2537551187 hasPublicationYear "2016" @default.
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