Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580470152> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2580470152 abstract "Abstract Abstract SCI-17 We have investigated the relationships between lineage-specific gene expression, and total genomic organization during hematopoiesis. First, we determined the linear chromosomal distribution of genes that are co-regulated (identified via microarray analysis) when murine hematopoietic progenitor cells (FDCP-mixA) are differentiated to the erythroid and neutrophil lineages, as well as the organization of all chromosomes (in the form of rosettes) in the three cell types. Our analysis revealed a significant tendency for co-regulated genes to be proximal, which is related to the association of homologous chromosomes and the spatial juxtaposition of lineage-specific gene domains. This led us to hypothesize that the genome—at the level of chromosomes—may self-organize to facilitate coordinate gene regulation during cellular differentiation. We tested this hypothesis by applying the approaches of distance matrices and coupled oscillators to our datasets of gene expression and chromosomal associations from the differentiation of the progenitor to the erythroid and neutrophil lineages. Our analysis revealed that coordinate gene expression undergoes a phase transition—characterized by an increase in entropy—upon commitment of the progenitor. As differentiation continues, there is a gradual loss of entropy, culminating in a highly ordered state in the differentiated cell types. The coregulated gene sets of the semi-ordered progenitor and ordered erythroid and neutrophil lineages are significantly correlated with lineage-specific chromosomal association patterns. Furthermore, by transforming the gene expression networks along the time course to corresponding chromosomal association matrices, we found that chromosomal topologies change dynamically during differentiation but, as with gene expression, result in a more highly ordered state in the differentiated cell types. Our analysis demonstrates that the networks of co-regulated gene expression and chromosomal association are mutually related during differentiation, resulting in the self-organization of lineage-specific chromosomal topologies. Disclosures No relevant conflicts of interest to declare." @default.
- W2580470152 created "2017-02-03" @default.
- W2580470152 creator A5000972985 @default.
- W2580470152 creator A5003856334 @default.
- W2580470152 creator A5030273254 @default.
- W2580470152 creator A5062073145 @default.
- W2580470152 creator A5062846476 @default.
- W2580470152 creator A5073932551 @default.
- W2580470152 date "2009-11-20" @default.
- W2580470152 modified "2023-09-30" @default.
- W2580470152 title "Dynamics of Genomic Organization." @default.
- W2580470152 doi "https://doi.org/10.1182/blood.v114.22.sci-17.sci-17" @default.
- W2580470152 hasPublicationYear "2009" @default.
- W2580470152 type Work @default.
- W2580470152 sameAs 2580470152 @default.
- W2580470152 citedByCount "0" @default.
- W2580470152 crossrefType "journal-article" @default.
- W2580470152 hasAuthorship W2580470152A5000972985 @default.
- W2580470152 hasAuthorship W2580470152A5003856334 @default.
- W2580470152 hasAuthorship W2580470152A5030273254 @default.
- W2580470152 hasAuthorship W2580470152A5062073145 @default.
- W2580470152 hasAuthorship W2580470152A5062846476 @default.
- W2580470152 hasAuthorship W2580470152A5073932551 @default.
- W2580470152 hasConcept C104317684 @default.
- W2580470152 hasConcept C109159458 @default.
- W2580470152 hasConcept C141231307 @default.
- W2580470152 hasConcept C148738053 @default.
- W2580470152 hasConcept C150194340 @default.
- W2580470152 hasConcept C201750760 @default.
- W2580470152 hasConcept C22322919 @default.
- W2580470152 hasConcept C28328180 @default.
- W2580470152 hasConcept C54355233 @default.
- W2580470152 hasConcept C5911399 @default.
- W2580470152 hasConcept C86803240 @default.
- W2580470152 hasConceptScore W2580470152C104317684 @default.
- W2580470152 hasConceptScore W2580470152C109159458 @default.
- W2580470152 hasConceptScore W2580470152C141231307 @default.
- W2580470152 hasConceptScore W2580470152C148738053 @default.
- W2580470152 hasConceptScore W2580470152C150194340 @default.
- W2580470152 hasConceptScore W2580470152C201750760 @default.
- W2580470152 hasConceptScore W2580470152C22322919 @default.
- W2580470152 hasConceptScore W2580470152C28328180 @default.
- W2580470152 hasConceptScore W2580470152C54355233 @default.
- W2580470152 hasConceptScore W2580470152C5911399 @default.
- W2580470152 hasConceptScore W2580470152C86803240 @default.
- W2580470152 hasLocation W25804701521 @default.
- W2580470152 hasOpenAccess W2580470152 @default.
- W2580470152 hasPrimaryLocation W25804701521 @default.
- W2580470152 hasRelatedWork W115952331 @default.
- W2580470152 hasRelatedWork W1511076147 @default.
- W2580470152 hasRelatedWork W1866708842 @default.
- W2580470152 hasRelatedWork W2012224745 @default.
- W2580470152 hasRelatedWork W2033585891 @default.
- W2580470152 hasRelatedWork W2038643289 @default.
- W2580470152 hasRelatedWork W2040912608 @default.
- W2580470152 hasRelatedWork W2047617397 @default.
- W2580470152 hasRelatedWork W2076458597 @default.
- W2580470152 hasRelatedWork W2077089071 @default.
- W2580470152 hasRelatedWork W2110741244 @default.
- W2580470152 hasRelatedWork W2127439151 @default.
- W2580470152 hasRelatedWork W2170174900 @default.
- W2580470152 hasRelatedWork W2296505930 @default.
- W2580470152 hasRelatedWork W2804456332 @default.
- W2580470152 hasRelatedWork W2807301917 @default.
- W2580470152 hasRelatedWork W2949685357 @default.
- W2580470152 hasRelatedWork W2969263411 @default.
- W2580470152 hasRelatedWork W3115492600 @default.
- W2580470152 hasRelatedWork W629812347 @default.
- W2580470152 isParatext "false" @default.
- W2580470152 isRetracted "false" @default.
- W2580470152 magId "2580470152" @default.
- W2580470152 workType "article" @default.