FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2590776674> ?p ?o ?g. }

• W2590776674 endingPage "e0172239" @default.
• W2590776674 startingPage "e0172239" @default.
• W2590776674 abstract "Background High sugar and refined carbohydrate intake is associated with weight gain, increased incidence of diabetes and is linked with increased cardiovascular mortality. Reducing the health impact of poor quality carbohydrate intake is a public health priority. Reducose, a proprietary mulberry leaf extract (ME), may reduce blood glucose responses following dietary carbohydrate intake by reducing absorption of glucose from the gut. Methods A double-blind, randomised, repeat measure, phase 2 crossover design was used to study the glycaemic and insulinaemic response to one reference product and three test products at the Functional Food Centre, Oxford Brooks University, UK. Participants; 37 adults aged 19–59 years with a BMI ≥ 20kg/m2 and ≤ 30kg/m2. The objective was to determine the effect of three doses of mulberry-extract (Reducose) versus placebo on blood glucose and insulin responses when co-administered with 50g maltodextrin in normoglycaemic healthy adults. We also report the gastrointestinal tolerability of the mulberry extract. Results Thirty-seven participants completed the study: The difference in the positive Incremental Area Under the Curve (pIAUC) (glucose (mmol / L x h)) for half, normal and double dose ME compared with placebo was -6.1% (-18.2%, 5.9%; p = 0.316), -14.0% (-26.0%, -2.0%; p = 0.022) and -22.0% (-33.9%, -10.0%; p<0.001) respectively. The difference in the pIAUC (insulin (mIU / L x h)) for half, normal and double dose ME compared with placebo was -9.7% (-25.8%, 6.3%; p = 0.234), -23.8% (-39.9%, -7.8%; p = 0.004) and -24.7% (-40.8%, -8.6%; p = 0.003) respectively. There were no statistically significant differences between any of the 4 groups in the odds of experiencing one or more gastrointestinal symptoms (nausea, abdominal cramping, distension or flatulence). Conclusions Mulberry leaf extract significantly reduces total blood glucose rise after ingestion of maltodextrin over 120 minutes. The pattern of effect demonstrates a classical dose response curve with significant effects over placebo. Importantly, total insulin rises were also significantly suppressed over the same time-period. There were no statistically significant differences between any of the treatment groups (including placebo) in the odds of experiencing one or more gastrointestinal symptoms. Mulberry extract may have multiple modes of action and further studies are necessary to evaluate ME as a potential target for the prevention of type 2 diabetes and the regulation of dysglycaemia." @default.
• W2590776674 created "2017-03-03" @default.
• W2590776674 creator A5006705453 @default.
• W2590776674 creator A5010398005 @default.
• W2590776674 creator A5037593087 @default.
• W2590776674 creator A5044276903 @default.
• W2590776674 creator A5068960794 @default.
• W2590776674 creator A5077471200 @default.
• W2590776674 creator A5090673306 @default.
• W2590776674 creator A5091500770 @default.
• W2590776674 date "2017-02-22" @default.
• W2590776674 modified "2023-10-16" @default.
• W2590776674 title "Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study" @default.
• W2590776674 cites W1958357891 @default.
• W2590776674 cites W1965726213 @default.
• W2590776674 cites W1967265218 @default.
• W2590776674 cites W1976010697 @default.
• W2590776674 cites W1979029388 @default.
• W2590776674 cites W1987608257 @default.
• W2590776674 cites W1987672280 @default.
• W2590776674 cites W2001395662 @default.
• W2590776674 cites W2007012006 @default.
• W2590776674 cites W2008900685 @default.
• W2590776674 cites W2014750665 @default.
• W2590776674 cites W2015312147 @default.
• W2590776674 cites W2018957993 @default.
• W2590776674 cites W2034766774 @default.
• W2590776674 cites W2063848448 @default.
• W2590776674 cites W2065949502 @default.
• W2590776674 cites W2071025291 @default.
• W2590776674 cites W2082721519 @default.
• W2590776674 cites W2091137098 @default.
• W2590776674 cites W2106273529 @default.
• W2590776674 cites W2115575518 @default.
• W2590776674 cites W2127180337 @default.
• W2590776674 cites W2131419387 @default.
• W2590776674 cites W2143518307 @default.
• W2590776674 cites W2149140350 @default.
• W2590776674 cites W2167783233 @default.
• W2590776674 cites W2168552382 @default.
• W2590776674 cites W2180537392 @default.
• W2590776674 doi "https://doi.org/10.1371/journal.pone.0172239" @default.
• W2590776674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5321430" @default.
• W2590776674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28225835" @default.
• W2590776674 hasPublicationYear "2017" @default.
• W2590776674 type Work @default.
• W2590776674 sameAs 2590776674 @default.
• W2590776674 citedByCount "40" @default.
• W2590776674 countsByYear W25907766742018 @default.
• W2590776674 countsByYear W25907766742019 @default.
• W2590776674 countsByYear W25907766742020 @default.
• W2590776674 countsByYear W25907766742021 @default.
• W2590776674 countsByYear W25907766742022 @default.
• W2590776674 countsByYear W25907766742023 @default.
• W2590776674 crossrefType "journal-article" @default.
• W2590776674 hasAuthorship W2590776674A5006705453 @default.
• W2590776674 hasAuthorship W2590776674A5010398005 @default.
• W2590776674 hasAuthorship W2590776674A5037593087 @default.
• W2590776674 hasAuthorship W2590776674A5044276903 @default.
• W2590776674 hasAuthorship W2590776674A5068960794 @default.
• W2590776674 hasAuthorship W2590776674A5077471200 @default.
• W2590776674 hasAuthorship W2590776674A5090673306 @default.
• W2590776674 hasAuthorship W2590776674A5091500770 @default.
• W2590776674 hasBestOaLocation W25907766741 @default.
• W2590776674 hasConcept C126322002 @default.
• W2590776674 hasConcept C134018914 @default.
• W2590776674 hasConcept C142724271 @default.
• W2590776674 hasConcept C197934379 @default.
• W2590776674 hasConcept C204787440 @default.
• W2590776674 hasConcept C27081682 @default.
• W2590776674 hasConcept C2777391703 @default.
• W2590776674 hasConcept C2778199505 @default.
• W2590776674 hasConcept C2778375690 @default.
• W2590776674 hasConcept C2778977261 @default.
• W2590776674 hasConcept C2779306644 @default.
• W2590776674 hasConcept C2780485761 @default.
• W2590776674 hasConcept C2780609358 @default.
• W2590776674 hasConcept C555293320 @default.
• W2590776674 hasConcept C71924100 @default.
• W2590776674 hasConcept C76318530 @default.
• W2590776674 hasConcept C87813604 @default.
• W2590776674 hasConcept C90924648 @default.
• W2590776674 hasConceptScore W2590776674C126322002 @default.
• W2590776674 hasConceptScore W2590776674C134018914 @default.
• W2590776674 hasConceptScore W2590776674C142724271 @default.
• W2590776674 hasConceptScore W2590776674C197934379 @default.
• W2590776674 hasConceptScore W2590776674C204787440 @default.
• W2590776674 hasConceptScore W2590776674C27081682 @default.
• W2590776674 hasConceptScore W2590776674C2777391703 @default.
• W2590776674 hasConceptScore W2590776674C2778199505 @default.
• W2590776674 hasConceptScore W2590776674C2778375690 @default.
• W2590776674 hasConceptScore W2590776674C2778977261 @default.
• W2590776674 hasConceptScore W2590776674C2779306644 @default.
• W2590776674 hasConceptScore W2590776674C2780485761 @default.
• W2590776674 hasConceptScore W2590776674C2780609358 @default.
• W2590776674 hasConceptScore W2590776674C555293320 @default.
• W2590776674 hasConceptScore W2590776674C71924100 @default.
• W2590776674 hasConceptScore W2590776674C76318530 @default.

• next