FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595290152> ?p ?o ?g. }

• W2595290152 abstract "The development of new multiphoton absorbing materials has attracted the attention of researchers for the last two decades. The advantages that multiphoton absorbing materials offer, versus their one-photon absorbing counterparts, rely on the nature of the nonlinearity of the absorption process, where two photons are absorbed simultaneously offering increased 3D resolution, deeper penetration, and less photobleaching and photodamage as a result of a more confined excitation. The applications of efficient two-photon absorbing materials have been extensively expanding into the fields of photodynamic therapy, microscopy, and optical data storage. One of the fields where an increased interest in multiphoton absorbing materials has been most evident is in bioimaging, in particular, when different cellular processes and organelles need to be studied by fluorescence microscopy. The goal of this research was to develop efficient two-photon absorption (2PA) compounds to be used in fluorescence bioimaging, meaning that such compounds need to posses good optical properties, such as high fluorescence quantum yield, 2PA cross section, and photostability. In the first chapter of this dissertation, we describe the synthesis and structural characterization of a new series of fluorescent donor–acceptor and acceptor-acceptor molecules based on the fluorenyl ring system that incorporated functionalities such as alkynes and thiophene rings, through efficient Pd-catalyzed Sonogashira and Stille coupling reactions, in order to increase the length of the conjugation in our systems. These new molecules proved to have high two-photon absorption (2PA), and the effect of these functionalities on their 2PA cross section values was evaluated. Finally, their use in two-photon fluorescence microscopy (2PFM) imaging was demonstrated. iii One of the limitations of the compounds described in Chapter 1 was their poor water solubility; this issue was addressed in Chapter 2. The use of micelles in drug delivery has been shown to be an area of increasing interest over the last decade. In the bioimaging field, it is key to have dye molecules with a high degree of water solubility to enable cells to uptake the dye. By enclosing a hydrophobic dye in Pluronic® F-127 micelles, we developed a system that facilitates the use of 2PA molecules (typically hydrophobic) in biological systems for nonlinear biophotonic applications, specifically to image the lysosomes. Furthermore, we report in this chapter the efficient microwave-assisted synthesis of the dye used in this study. In addition, linear photophysical and photochemical parameters, two-photon absorption (2PA), and superfluorescence properties of the dye studied in Chapter 2, were investigated in Chapter 3. The steady-state absorption, fluorescence, and excitation anisotropy spectra of this dye were measured in several organic solvents and aqueous media. In Chapter 4, we describe the preparation and the use of an efficient and novel twophoton absorbing fluorescent probe conjugated to an antibody that confers…" @default.
• W2595290152 created "2017-03-23" @default.
• W2595290152 creator A5027081155 @default.
• W2595290152 date "2010-01-01" @default.
• W2595290152 modified "2023-10-17" @default.
• W2595290152 title "Design, Synthesis And Characterization Of New Two-photon Absorbing (2pa) Fluorescent Dyes And Bioconjugates, And Their Applications In Bioimaging" @default.
• W2595290152 cites W1490489189 @default.
• W2595290152 cites W1549799773 @default.
• W2595290152 cites W1769272814 @default.
• W2595290152 cites W1903105706 @default.
• W2595290152 cites W1967390103 @default.
• W2595290152 cites W1968827790 @default.
• W2595290152 cites W1969154683 @default.
• W2595290152 cites W1972655982 @default.
• W2595290152 cites W1973921444 @default.
• W2595290152 cites W1975017351 @default.
• W2595290152 cites W1980102069 @default.
• W2595290152 cites W1985793906 @default.
• W2595290152 cites W1985972866 @default.
• W2595290152 cites W1987010189 @default.
• W2595290152 cites W1987406930 @default.
• W2595290152 cites W1990775595 @default.
• W2595290152 cites W1991262047 @default.
• W2595290152 cites W1991815226 @default.
• W2595290152 cites W1992962372 @default.
• W2595290152 cites W1993759736 @default.
• W2595290152 cites W1994413411 @default.
• W2595290152 cites W1995997812 @default.
• W2595290152 cites W1999663096 @default.
• W2595290152 cites W2003342170 @default.
• W2595290152 cites W2006051415 @default.
• W2595290152 cites W2006837379 @default.
• W2595290152 cites W2014046899 @default.
• W2595290152 cites W2014215384 @default.
• W2595290152 cites W2015867957 @default.
• W2595290152 cites W2015886513 @default.
• W2595290152 cites W2016005552 @default.
• W2595290152 cites W2016238530 @default.
• W2595290152 cites W2016683300 @default.
• W2595290152 cites W2019227546 @default.
• W2595290152 cites W2019649880 @default.
• W2595290152 cites W2022050193 @default.
• W2595290152 cites W2022798526 @default.
• W2595290152 cites W2024536147 @default.
• W2595290152 cites W2024926712 @default.
• W2595290152 cites W2026754162 @default.
• W2595290152 cites W2029283158 @default.
• W2595290152 cites W2031639008 @default.
• W2595290152 cites W2034640266 @default.
• W2595290152 cites W2036459378 @default.
• W2595290152 cites W2036736151 @default.
• W2595290152 cites W2039857764 @default.
• W2595290152 cites W2041625732 @default.
• W2595290152 cites W2043540507 @default.
• W2595290152 cites W2043764425 @default.
• W2595290152 cites W2047262201 @default.
• W2595290152 cites W2050044028 @default.
• W2595290152 cites W2052551388 @default.
• W2595290152 cites W2054147365 @default.
• W2595290152 cites W2054455698 @default.
• W2595290152 cites W2061464631 @default.
• W2595290152 cites W2061473417 @default.
• W2595290152 cites W2063204257 @default.
• W2595290152 cites W2065155254 @default.
• W2595290152 cites W2066374954 @default.
• W2595290152 cites W2067434639 @default.
• W2595290152 cites W2068926508 @default.
• W2595290152 cites W2070983519 @default.
• W2595290152 cites W2074557884 @default.
• W2595290152 cites W2080093188 @default.
• W2595290152 cites W2084740377 @default.
• W2595290152 cites W2085360086 @default.
• W2595290152 cites W2087279809 @default.
• W2595290152 cites W2089353178 @default.
• W2595290152 cites W2091723156 @default.
• W2595290152 cites W2092001098 @default.
• W2595290152 cites W2097881540 @default.
• W2595290152 cites W2100525694 @default.
• W2595290152 cites W2101580222 @default.
• W2595290152 cites W2107919129 @default.
• W2595290152 cites W2109168096 @default.
• W2595290152 cites W2115737236 @default.
• W2595290152 cites W2115896691 @default.
• W2595290152 cites W2119306076 @default.
• W2595290152 cites W2126460855 @default.
• W2595290152 cites W2127353705 @default.
• W2595290152 cites W2128583282 @default.
• W2595290152 cites W2129995310 @default.
• W2595290152 cites W2141821787 @default.
• W2595290152 cites W2144026946 @default.
• W2595290152 cites W2145767709 @default.
• W2595290152 cites W2152043216 @default.
• W2595290152 cites W2153497035 @default.
• W2595290152 cites W2163593130 @default.
• W2595290152 cites W2167460696 @default.
• W2595290152 cites W2274550965 @default.
• W2595290152 cites W2325758248 @default.
• W2595290152 cites W276436992 @default.
• W2595290152 cites W2798683442 @default.
• W2595290152 hasPublicationYear "2010" @default.

• next