Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600527632> ?p ?o ?g. }
- W2600527632 endingPage "2818" @default.
- W2600527632 startingPage "2811" @default.
- W2600527632 abstract "Hepatitis B virus (HBV) is mainly suspected to promote hepatocellular carcinoma (HCC) development by epigenetic alteration. The HBV X protein (HBx) plays a key role in the molecular pathogenesis of HBV-related HCC. However, the mechanism of HBx-mediated hepatocarcinogenesis remains to be elucidated. RIZ1 gene, a candidate HCC suppressor gene, is frequently found to be hypermethylated and downregulated in HCC. In the present study, we show that the expression of RIZ1 was downregulated in 65% HCC tissues. Decreased expression of RIZ1 was restored by 5'-Aza in MHCC-97H HCC cell lines. HBx recombinant transfection increased DNMT1 expression level and suppressed RIZ1 expression. Moreover, knockdown of DNMT1 by siRNA restored RIZ1 expression in HCC cell SMMC-7721 and reduced methylated CpG sites of RIZ1. ChIP results showed that DNMT1 protein could bind to RIZ1 promoter, and this interaction was further enhanced with the transfected HBX recombinant. Moreover, miR-152 was decreased and involved in upregulation of DNMT1 in HBx transfected cells, at least partly, contributed to the epigenetic inactivation of RIZ1. Taken together, our data found that HBx repressed RIZ1 expression via DNMT1, which offered a new mechanism of RIZ1 inactivation in HCC, except for the widely known DNA methylation. These results enriched the epigenetic mechanism by which HBx contributes to pathogenesis of HBV-HCC." @default.
- W2600527632 created "2017-04-07" @default.
- W2600527632 creator A5007957123 @default.
- W2600527632 creator A5010215325 @default.
- W2600527632 creator A5013580238 @default.
- W2600527632 creator A5017445263 @default.
- W2600527632 creator A5021532810 @default.
- W2600527632 creator A5040485370 @default.
- W2600527632 creator A5043819331 @default.
- W2600527632 creator A5060264631 @default.
- W2600527632 creator A5060363049 @default.
- W2600527632 creator A5063537750 @default.
- W2600527632 creator A5080377214 @default.
- W2600527632 creator A5083614314 @default.
- W2600527632 creator A5086543492 @default.
- W2600527632 date "2017-03-21" @default.
- W2600527632 modified "2023-09-26" @default.
- W2600527632 title "HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinoma" @default.
- W2600527632 cites W1496933509 @default.
- W2600527632 cites W1973648526 @default.
- W2600527632 cites W1976118924 @default.
- W2600527632 cites W1979717427 @default.
- W2600527632 cites W1981554930 @default.
- W2600527632 cites W1988594157 @default.
- W2600527632 cites W1989661484 @default.
- W2600527632 cites W1990349961 @default.
- W2600527632 cites W1999382524 @default.
- W2600527632 cites W2003825154 @default.
- W2600527632 cites W2018243060 @default.
- W2600527632 cites W2020717559 @default.
- W2600527632 cites W2030607381 @default.
- W2600527632 cites W2036169252 @default.
- W2600527632 cites W2037049165 @default.
- W2600527632 cites W2039226560 @default.
- W2600527632 cites W2044417339 @default.
- W2600527632 cites W2048280970 @default.
- W2600527632 cites W2056768380 @default.
- W2600527632 cites W2058916559 @default.
- W2600527632 cites W2065284473 @default.
- W2600527632 cites W2076969582 @default.
- W2600527632 cites W2076983714 @default.
- W2600527632 cites W2083865595 @default.
- W2600527632 cites W2088695782 @default.
- W2600527632 cites W2096808350 @default.
- W2600527632 cites W2099107945 @default.
- W2600527632 cites W2111583453 @default.
- W2600527632 cites W2114556977 @default.
- W2600527632 cites W2140532234 @default.
- W2600527632 cites W2207768441 @default.
- W2600527632 cites W2417468510 @default.
- W2600527632 cites W4243625103 @default.
- W2600527632 cites W4322378258 @default.
- W2600527632 doi "https://doi.org/10.3892/or.2017.5518" @default.
- W2600527632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28339081" @default.
- W2600527632 hasPublicationYear "2017" @default.
- W2600527632 type Work @default.
- W2600527632 sameAs 2600527632 @default.
- W2600527632 citedByCount "24" @default.
- W2600527632 countsByYear W26005276322017 @default.
- W2600527632 countsByYear W26005276322018 @default.
- W2600527632 countsByYear W26005276322019 @default.
- W2600527632 countsByYear W26005276322020 @default.
- W2600527632 countsByYear W26005276322021 @default.
- W2600527632 countsByYear W26005276322022 @default.
- W2600527632 countsByYear W26005276322023 @default.
- W2600527632 crossrefType "journal-article" @default.
- W2600527632 hasAuthorship W2600527632A5007957123 @default.
- W2600527632 hasAuthorship W2600527632A5010215325 @default.
- W2600527632 hasAuthorship W2600527632A5013580238 @default.
- W2600527632 hasAuthorship W2600527632A5017445263 @default.
- W2600527632 hasAuthorship W2600527632A5021532810 @default.
- W2600527632 hasAuthorship W2600527632A5040485370 @default.
- W2600527632 hasAuthorship W2600527632A5043819331 @default.
- W2600527632 hasAuthorship W2600527632A5060264631 @default.
- W2600527632 hasAuthorship W2600527632A5060363049 @default.
- W2600527632 hasAuthorship W2600527632A5063537750 @default.
- W2600527632 hasAuthorship W2600527632A5080377214 @default.
- W2600527632 hasAuthorship W2600527632A5083614314 @default.
- W2600527632 hasAuthorship W2600527632A5086543492 @default.
- W2600527632 hasBestOaLocation W26005276321 @default.
- W2600527632 hasConcept C104317684 @default.
- W2600527632 hasConcept C121608353 @default.
- W2600527632 hasConcept C140173407 @default.
- W2600527632 hasConcept C150194340 @default.
- W2600527632 hasConcept C153911025 @default.
- W2600527632 hasConcept C159047783 @default.
- W2600527632 hasConcept C173396325 @default.
- W2600527632 hasConcept C175211621 @default.
- W2600527632 hasConcept C190727270 @default.
- W2600527632 hasConcept C2522874641 @default.
- W2600527632 hasConcept C2779979206 @default.
- W2600527632 hasConcept C2780593183 @default.
- W2600527632 hasConcept C2781018059 @default.
- W2600527632 hasConcept C29537977 @default.
- W2600527632 hasConcept C33288867 @default.
- W2600527632 hasConcept C41091548 @default.
- W2600527632 hasConcept C502942594 @default.
- W2600527632 hasConcept C54009773 @default.