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- W2600891687 abstract "e22144 Background: To improve targeting and to reduce the side effects of drugs is the key to improve the efficacy of chemotherapy. Polymer micelle is the hot topic in the field of anticancer drugs in recent years. Methods: Based on the understanding of the liver reticuloendothelial system (RES), the principle of tumor EPR passive targeting effect, the selective uptake of the organ, and active targeting, the present paper reports a novel smart drug delivery system (DDS), designs and prepares Doxorubicin-conjugates and in situ liver cancer animal models. In order to compare the partitions of the nano-micelles in the cancerous tissue and in the healthy part of the liver due to the RES capture and the EPR effect, the novel predrug composes of various targeting molecules, such as folic acid, tripeptide arginine-glycine-aspartic acid (RGD) and lactose, which overexpress in the vascular endothelial cells and epithelial solid carcinoma, or liver tumor cells. Results: This DDS has a satisfactory drug loadi..." @default.
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- W2600891687 date "2014-05-20" @default.
- W2600891687 modified "2023-09-26" @default.
- W2600891687 title "Targeting mPEG-poly (lactide-co-glycplide) drug-loaded nano-micelles inhibit liver cancer." @default.
- W2600891687 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e22144" @default.
- W2600891687 hasPublicationYear "2014" @default.
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