Matches in SemOpenAlex for { <https://semopenalex.org/work/W2619874725> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2619874725 endingPage "19" @default.
- W2619874725 startingPage "13" @default.
- W2619874725 abstract "Human sterol <TEX>${Delta}8-{Delta}7$</TEX> isomerase, commonly known as emopamil binding protein (EBP), is an essential protein in the cholesterol-synthetic pathway, and mutations of this protein are critically associated with human diseases such as Conradi-Hunermann-Happle or male EBP disorder with neurological defects syndrome. Due to such a clinical importance, EBP has been intensively investigated and some important features have been reported. EBP is a tetra-spanning membrane protein, of which <TEX>$2^{nd}$</TEX>, <TEX>$3^{rd}$</TEX>, and <TEX>$4^{th}$</TEX> membrane-spanning <TEX>${alpha}$</TEX> helices play an important role in its enzymatic function. However, detailed structural feature at atomic resolution has not yet been elucidated, due to characteristic difficulties in dealing with membrane protein. Here, we over-expressed EBP using Escherichia coli and performed detergent screening to find suitable membrane mimetics for structural studies of the protein by NMR. As results, DPC and LMPG could be evaluated as the most favorable detergents to acquire promising NMR spectra for structural study of EBP." @default.
- W2619874725 created "2017-06-05" @default.
- W2619874725 creator A5031870659 @default.
- W2619874725 date "2017-03-20" @default.
- W2619874725 modified "2023-09-26" @default.
- W2619874725 title "Detergent Screening for NMR-Based Structural Study of the Integral Membrane Protein, Emopamil Binding Protein (Human Sterol Δ8-Δ7 Isomerase)" @default.
- W2619874725 doi "https://doi.org/10.6564/jkmrs.2017.21.1.013" @default.
- W2619874725 hasPublicationYear "2017" @default.
- W2619874725 type Work @default.
- W2619874725 sameAs 2619874725 @default.
- W2619874725 citedByCount "0" @default.
- W2619874725 crossrefType "journal-article" @default.
- W2619874725 hasAuthorship W2619874725A5031870659 @default.
- W2619874725 hasBestOaLocation W26198747251 @default.
- W2619874725 hasConcept C104317684 @default.
- W2619874725 hasConcept C14036430 @default.
- W2619874725 hasConcept C144647389 @default.
- W2619874725 hasConcept C161200384 @default.
- W2619874725 hasConcept C181199279 @default.
- W2619874725 hasConcept C185592680 @default.
- W2619874725 hasConcept C2778163477 @default.
- W2619874725 hasConcept C2778718757 @default.
- W2619874725 hasConcept C2781264208 @default.
- W2619874725 hasConcept C41625074 @default.
- W2619874725 hasConcept C547475151 @default.
- W2619874725 hasConcept C55493867 @default.
- W2619874725 hasConcept C86803240 @default.
- W2619874725 hasConcept C95444343 @default.
- W2619874725 hasConceptScore W2619874725C104317684 @default.
- W2619874725 hasConceptScore W2619874725C14036430 @default.
- W2619874725 hasConceptScore W2619874725C144647389 @default.
- W2619874725 hasConceptScore W2619874725C161200384 @default.
- W2619874725 hasConceptScore W2619874725C181199279 @default.
- W2619874725 hasConceptScore W2619874725C185592680 @default.
- W2619874725 hasConceptScore W2619874725C2778163477 @default.
- W2619874725 hasConceptScore W2619874725C2778718757 @default.
- W2619874725 hasConceptScore W2619874725C2781264208 @default.
- W2619874725 hasConceptScore W2619874725C41625074 @default.
- W2619874725 hasConceptScore W2619874725C547475151 @default.
- W2619874725 hasConceptScore W2619874725C55493867 @default.
- W2619874725 hasConceptScore W2619874725C86803240 @default.
- W2619874725 hasConceptScore W2619874725C95444343 @default.
- W2619874725 hasIssue "1" @default.
- W2619874725 hasLocation W26198747251 @default.
- W2619874725 hasOpenAccess W2619874725 @default.
- W2619874725 hasPrimaryLocation W26198747251 @default.
- W2619874725 hasRelatedWork W1769442777 @default.
- W2619874725 hasRelatedWork W2019656894 @default.
- W2619874725 hasRelatedWork W2020405150 @default.
- W2619874725 hasRelatedWork W2047788323 @default.
- W2619874725 hasRelatedWork W2050917233 @default.
- W2619874725 hasRelatedWork W2107495659 @default.
- W2619874725 hasRelatedWork W2199584405 @default.
- W2619874725 hasRelatedWork W2419351841 @default.
- W2619874725 hasRelatedWork W2745500882 @default.
- W2619874725 hasRelatedWork W2790334126 @default.
- W2619874725 hasVolume "21" @default.
- W2619874725 isParatext "false" @default.
- W2619874725 isRetracted "false" @default.
- W2619874725 magId "2619874725" @default.
- W2619874725 workType "article" @default.