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- W2625399403 abstract "Ascorbic acid (vitamin C) is a co-factor required in catecholamine synthesis for conversion of dopamine to norepinephrine by dopamine beta-hydroxylase. Mutant mice lacking plasma membrane ascorbic acid transporter (SVCT2) have severely reduced tissue ascorbic acid levels and die after birth. We investigated whether these mice might also present impaired catecholamine synthesis. Brain catecholamine levels were unaffected by SVCT2 deficiency. In cardiac tissue, the only evidence for impaired dopamine beta-hydroxylase activity was a twofold increase in tissue dopamine. An influence of the deficiency on tissue catecholamines was most prominent in the adrenals, where norepinephrine was decreased by 50% and epinephrine by 81%. On an ultrastructural level, adrenal chromaffin cells in SVCT2-null mice showed depleted catecholamine storage vesicles, increased rough endoplasmic reticulum, signs of apoptosis, and increased glycogen storage. Decreased plasma corticosterone levels indicated that SVCT2 deficiency also affected adrenocortical function. These data show that deranged catecholamine system function in SVCT2-null mice is largely restricted to the adrenal medulla and cannot account for the lethality in these animals. The data, however, establish a crucial role for ascorbic acid in adrenal chromaffin cell function." @default.
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- W2625399403 date "2004-09-17" @default.
- W2625399403 modified "2023-09-26" @default.
- W2625399403 title "Vitamin C Transporter Knock-out Leads to Severe Impairment of Adrenal Function" @default.
- W2625399403 doi "https://doi.org/10.1055/s-2004-830830" @default.
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