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• W2682208191 abstract "2528 Background: Response-classification-systems, e.g. RECIST1.1, and dedicated oncology software-tools (DOST) are used to standardize response assessment. Expectation is that different readers should yield the same response-classification for any given patient. We investigated real-life variability between readers who, as in clinical practice, were free to select target-lesions (TL). Methods: Prospective study on 316 patients with metastatic disease who underwent 932 CT-studies, yielding a total 616 follow-up occasions (baseline vs. follow-up) for analysis. All CT-studies were independently evaluated by 3 radiologists who used state-of-the-art DOST (MintLesion). Readers were free to select TL in the respective baseline study, and did so independently. Kappa-statistics were used to analyse agreement for RECIST1.1 response-class-assignment depending on whether readers had selected the same or different TL.To investigate possible impact on treatment decisions, agreement was also determined after aggregating response classes into progressive (PD) vs. non-progressive (CR/PR/SD). Results: Readers used the same TL in 38.6 (238/616), different in 61.4% (378/616). Where readers happened to select the same TL, agreement was “almost perfect” (κ = 0.966 [96%-CI: 0.912–1.00] for assignment of individual response-classes, and 0.977 [0.898–1.0] for the distinction progressive-vs-non-progressive). Where readers had selected different TL, agreement was only “moderate” (0.583 [0.541–0.624] for individual response-class-assignment, and 0.644 [0.587 to 0.701] for distinction progressive-vs.-non-progressive). Choice of the same TL was associated with agreement for distinction between progressive-vs.-non-progressive-disease in 97.7 % [95.4%–100.0%] of patients; choice of different TL was associated with disagreement in 44.7% [37.6%–51.8%]. Conclusions: If different radiologists use RECIST1.1 and DOST for response assessment, they will select different TL more often than not. Just depending on whether TL selection was concordant or not, radiologists will exhibit perfect agreement, or substantial disagreement, even for distinguishing progressive vs non-progressive disease." @default.
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• W2682208191 date "2017-05-20" @default.
• W2682208191 modified "2023-09-27" @default.
• W2682208191 title "Effect of target lesions selection on between-reader variability of response assessment according to RECIST 1.1." @default.
• W2682208191 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.2528" @default.
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