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• W2725773065 abstract "There is now a resurgent interest in the role of mitochondria in cancer. Long considered controversial or outright unimportant, mitochondrial biology is now increasingly recognised as an important tumour driver. The underlying mechanisms remain to be fully elucidated. But recent studies have uncovered a complex landscape where reprogramming of mitochondrial homoeostasis, including organelle dynamics, metabolic output, apoptosis control and redox status converge to promote tumour adaptation to an unfavourable microenvironment and inject new traits of aggressive disease. In particular, mechanisms of subcellular mitochondrial trafficking have unexpectedly emerged as central regulators of metastatic competence in disparate tumours. Some of these pathways are druggable, opening fresh therapeutic opportunities for advanced and disseminated disease." @default.
• W2725773065 created "2017-07-14" @default.
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• W2725773065 date "2017-07-01" @default.
• W2725773065 modified "2023-10-14" @default.
• W2725773065 title "Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis" @default.
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• W2725773065 doi "https://doi.org/10.1038/bjc.2017.201" @default.
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