FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754366826> ?p ?o ?g. }

• W2754366826 endingPage "10460" @default.
• W2754366826 startingPage "10455" @default.
• W2754366826 abstract "Significance The survival benefit of antiangiogenic therapies for cancer patients has been limited, potentially due to intrinsic/acquired resistance. Deciphering and targeting resistance mechanisms are critical to improving treatment outcome, especially in cancers where antiangiogenic therapies are standard of care, such as colorectal cancer (CRC). Consistent with our clinical findings, we found up-regulation of CXCL12/CXCR4 in orthotopic CRC models and conditional Apc mutant spontaneous rectal tumors after anti-VEGFR2 treatment. CXCR4 signaling recruited immunosuppressive innate immune cells such as Ly6C low monocytes and Ly6G + neutrophils to the CRCs, conferring resistance to VEGFR2 blockade. Furthermore, we successfully targeted these pathways genetically and pharmacologically, including with an FDA-approved agent Plerixafor (AMD3100), which significantly enhanced treatment response. These strategies have the potential for rapid clinical translation." @default.
• W2754366826 created "2017-09-25" @default.
• W2754366826 creator A5012765342 @default.
• W2754366826 creator A5015585176 @default.
• W2754366826 creator A5017916544 @default.
• W2754366826 creator A5017936529 @default.
• W2754366826 creator A5018814083 @default.
• W2754366826 creator A5028060907 @default.
• W2754366826 creator A5038803108 @default.
• W2754366826 creator A5044970408 @default.
• W2754366826 creator A5046634176 @default.
• W2754366826 creator A5051870010 @default.
• W2754366826 creator A5055058026 @default.
• W2754366826 creator A5055995920 @default.
• W2754366826 creator A5056855398 @default.
• W2754366826 creator A5058193717 @default.
• W2754366826 creator A5065827707 @default.
• W2754366826 creator A5066969091 @default.
• W2754366826 creator A5077118035 @default.
• W2754366826 creator A5088474933 @default.
• W2754366826 date "2017-09-12" @default.
• W2754366826 modified "2023-10-16" @default.
• W2754366826 title "Targeting CXCR4-dependent immunosuppressive Ly6C ^low monocytes improves antiangiogenic therapy in colorectal cancer" @default.
• W2754366826 cites W1543575007 @default.
• W2754366826 cites W1659892149 @default.
• W2754366826 cites W1971620413 @default.
• W2754366826 cites W1977102146 @default.
• W2754366826 cites W1977999028 @default.
• W2754366826 cites W1984642649 @default.
• W2754366826 cites W1993728889 @default.
• W2754366826 cites W1993918137 @default.
• W2754366826 cites W2000622589 @default.
• W2754366826 cites W2007444707 @default.
• W2754366826 cites W2010800009 @default.
• W2754366826 cites W2011615632 @default.
• W2754366826 cites W2018639932 @default.
• W2754366826 cites W2019011312 @default.
• W2754366826 cites W2022540958 @default.
• W2754366826 cites W2026578487 @default.
• W2754366826 cites W2026996188 @default.
• W2754366826 cites W2028309086 @default.
• W2754366826 cites W2037751912 @default.
• W2754366826 cites W2038233531 @default.
• W2754366826 cites W2042797183 @default.
• W2754366826 cites W2066671159 @default.
• W2754366826 cites W2066735451 @default.
• W2754366826 cites W2080202443 @default.
• W2754366826 cites W2080844075 @default.
• W2754366826 cites W2083797848 @default.
• W2754366826 cites W2086049503 @default.
• W2754366826 cites W2088113798 @default.
• W2754366826 cites W2099604050 @default.
• W2754366826 cites W2102055984 @default.
• W2754366826 cites W2102152192 @default.
• W2754366826 cites W2109134893 @default.
• W2754366826 cites W2109527439 @default.
• W2754366826 cites W2122403898 @default.
• W2754366826 cites W2130870648 @default.
• W2754366826 cites W2135647797 @default.
• W2754366826 cites W2139877124 @default.
• W2754366826 cites W2142167347 @default.
• W2754366826 cites W2149177522 @default.
• W2754366826 cites W2161057248 @default.
• W2754366826 cites W2165340922 @default.
• W2754366826 cites W2168234885 @default.
• W2754366826 cites W2168631000 @default.
• W2754366826 cites W2253777559 @default.
• W2754366826 cites W2266683146 @default.
• W2754366826 cites W2279561773 @default.
• W2754366826 cites W2294927533 @default.
• W2754366826 cites W2340636398 @default.
• W2754366826 cites W2359522094 @default.
• W2754366826 cites W2465158514 @default.
• W2754366826 cites W2520601585 @default.
• W2754366826 cites W2530012709 @default.
• W2754366826 cites W2530903079 @default.
• W2754366826 cites W2726768474 @default.
• W2754366826 cites W940185179 @default.
• W2754366826 doi "https://doi.org/10.1073/pnas.1710754114" @default.
• W2754366826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5625928" @default.
• W2754366826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28900008" @default.
• W2754366826 hasPublicationYear "2017" @default.
• W2754366826 type Work @default.
• W2754366826 sameAs 2754366826 @default.
• W2754366826 citedByCount "94" @default.
• W2754366826 countsByYear W27543668262018 @default.
• W2754366826 countsByYear W27543668262019 @default.
• W2754366826 countsByYear W27543668262020 @default.
• W2754366826 countsByYear W27543668262021 @default.
• W2754366826 countsByYear W27543668262022 @default.
• W2754366826 countsByYear W27543668262023 @default.
• W2754366826 crossrefType "journal-article" @default.
• W2754366826 hasAuthorship W2754366826A5012765342 @default.
• W2754366826 hasAuthorship W2754366826A5015585176 @default.
• W2754366826 hasAuthorship W2754366826A5017916544 @default.
• W2754366826 hasAuthorship W2754366826A5017936529 @default.
• W2754366826 hasAuthorship W2754366826A5018814083 @default.
• W2754366826 hasAuthorship W2754366826A5028060907 @default.

• next