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- W2765740666 abstract "Early and accurate diagnosis of Alzheimer's disease (AD) remains central to studying the pathophysiology of AD and to clinical trials aimed at altering disease course. Event-related potentials (ERPs), a type of quantitative electroencephalogram (EEG), are a potential biomarker of AD. Altered ERP signals have been demonstrated in the progression and subsequent conversion to dementia in mild cognitive impairment (MCI) (Papaliagkas, 2011), and have also been detected in presymptomatic individuals (Quiroz et al., 2011). Although ERPs have the potential to be sensitive biomarkers with low cost and low invasiveness, the promise of this technique in clinical practice has not yet been fully realized. Thirty-eight subjects who presented with memory loss underwent standard clinical workup including history and physical, neuroimaging, laboratory studies, and a neuropsychological battery, leading to a clinical diagnosis. All subjects consented to an ERP session using a three-tone auditory oddball paradigm with a seven-electrode device. ERP results were reviewed by two behavioral neurologists blinded to the clinical details of each subject. Amplitude and latency of ERP peaks were rated in the AD or healthy older adult range (Cecchi et al 2015). The total sum of the number of peaks in the diseased range was computed and a diagnostic rating was made for each ERP study as consistent with MCI due to AD, mild AD, moderate AD, or inconsistent with AD. Spearman's correlation showed that the total number of ERP peaks that fell into the mild AD range correlated inversely with Montreal Cognitive Assessment (MOCA); correlation coefficient of -.535 and p-value of .001. (Figure 1)." @default.
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- W2765740666 date "2017-07-01" @default.
- W2765740666 modified "2023-09-27" @default.
- W2765740666 title "[P2-225]: UTILITY OF EVENT-RELATED POTENTIALS IN A MEMORY DISORDERS CLINIC" @default.
- W2765740666 doi "https://doi.org/10.1016/j.jalz.2017.06.877" @default.
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