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• W2765741957 abstract "Growing evidence suggests an association between sleep-disordered breathing (SDB) and cognitive aging in the elderly. However, results from population-based studies have been conflicting, possibly due to different methods to assess SDB or cognitive domains, making it difficult to draw conclusions on this association. We performed a systematic search of publications (in English) using PubMed, EMBASE and PsychINFO. We included cross-sectional and prospective studies with at least 200 participants, average participant age of ≥ 40 years, SDB ascertained by apnea-hypopnea index (AHI) or clinical diagnosis, and cognitive outcomes based on standard tests or diagnosis of cognitive impairment. We extracted and pooled adjusted risk ratios from prospective studies and standard mean differences (SMD) from cross-sectional studies, using random-effect models. We focused on three cognitive domains: global cognition, executive function and delayed memory. We tested heterogeneity between studies using the I2 statistics, and used Egger test and funnel plot asymmetry to evaluate publication bias. We included 14 studies, six of which were prospective, covering a total of 4,288,419 men and women. Pooled analysis of the six prospective studies indicated that those with SDB were 26% (RR= 1.26; 95% CI: 1.05–1.50) more likely to develop cognitive impairment, with no evidence of publication bias (p=0.74) but heterogeneity between studies (p=0.04). After removing one study that introduced significant heterogeneity, the pooled RR was 1.35 (95% CI: 1.11–1.65). Pooled analysis of the seven cross-sectional studies suggested that those with SDB had slightly worse executive function (SMD=-0.05; 95%CI: -0.09–0.00), with no evidence of heterogeneity (p=0.31) or publication bias (p=0.65). SDB was not associated with global cognition or memory. SDB is associated with an increased risk of cognitive impairment and a small worsening in executive function but not with other cognitive domains. Further studies are required to determine mechanisms linking these common conditions and if treatment of SDB might reduce risk of cognitive impairment." @default.
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• W2765741957 date "2017-07-01" @default.
• W2765741957 modified "2023-09-27" @default.
• W2765741957 title "[P1-033]: SLEEP-DISORDERED BREATHING, COGNITIVE FUNCTION AND RISK OF COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS" @default.
• W2765741957 doi "https://doi.org/10.1016/j.jalz.2017.06.100" @default.
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