Matches in SemOpenAlex for { <https://semopenalex.org/work/W2766265212> ?p ?o ?g. }
- W2766265212 endingPage "1308" @default.
- W2766265212 startingPage "1300" @default.
- W2766265212 abstract "Coiled Coil Domain Containing 6 gene, CCDC6, was initially isolated as part of a tumorigenic DNA originated by the fusion of CCDC6 with the tyrosine kinase of RET receptor, following a paracentric inversion of chromosome 10. For a long time, CCDC6 has been considered as an accidental partner of the RET protooncogene, providing the promoter and the first 101 aa necessary for the constitutive activation of the oncogenic Tyrosine Kinase (TK) RET in thyroid cells. With the advent of more refined diagnostic tools and bioinformatic algorithms, an exponential growth in fusion genes discoveries has allowed the identification of CCDC6 as partner of genes other than RET in different tumor types. CCDC6 gene product has a proper role in sustaining the DNA damage checkpoints in response to DNA damage. The inactivation of CCDC6 secondary to chromosomal rearrangements or gene mutations could enhance tumor progression by impairing the apoptotic response upon the DNA damage exposure, contributing to the generation of radio- and chemoresistance. Preclinical studies indicate that the attenuation of CCDC6 in cancer, while conferring a resistance to cisplatinum, sensitizes the cancer cells to the small molecule inhibitors of Poly (ADP-ribose) polymerase (PARP1/2) with a synthetic lethal effect. Several CCDC6 mutations and gene rearrangements have been described so far in different types of cancer and CCDC6 may represent a possible predictive biomarker of tumor resistance to the conventional anticancer treatments. Nevertheless, the detection of a CCDC6 impairment in cancer patients may help to select, in future clinical trials, those patients who could benefit of PARP-inhibitors treatment alone or in combination with other treatments." @default.
- W2766265212 created "2017-11-10" @default.
- W2766265212 creator A5011546047 @default.
- W2766265212 creator A5047959368 @default.
- W2766265212 creator A5061495027 @default.
- W2766265212 creator A5087281898 @default.
- W2766265212 date "2017-10-26" @default.
- W2766265212 modified "2023-10-01" @default.
- W2766265212 title "CCDC6: the identity of a protein known to be partner in fusion" @default.
- W2766265212 cites W1653933658 @default.
- W2766265212 cites W1810761522 @default.
- W2766265212 cites W1832813974 @default.
- W2766265212 cites W1875361486 @default.
- W2766265212 cites W1877179823 @default.
- W2766265212 cites W189193503 @default.
- W2766265212 cites W1899841688 @default.
- W2766265212 cites W1963220545 @default.
- W2766265212 cites W1963634449 @default.
- W2766265212 cites W1971223620 @default.
- W2766265212 cites W1972991017 @default.
- W2766265212 cites W1976498645 @default.
- W2766265212 cites W1979546531 @default.
- W2766265212 cites W1982745900 @default.
- W2766265212 cites W1984080345 @default.
- W2766265212 cites W1984504725 @default.
- W2766265212 cites W1984874459 @default.
- W2766265212 cites W1985428767 @default.
- W2766265212 cites W1988202771 @default.
- W2766265212 cites W1992118957 @default.
- W2766265212 cites W1998594146 @default.
- W2766265212 cites W2010408856 @default.
- W2766265212 cites W2022897106 @default.
- W2766265212 cites W2031482561 @default.
- W2766265212 cites W2044178246 @default.
- W2766265212 cites W2049930674 @default.
- W2766265212 cites W2051802352 @default.
- W2766265212 cites W2052179498 @default.
- W2766265212 cites W2053987947 @default.
- W2766265212 cites W2055512533 @default.
- W2766265212 cites W2062750863 @default.
- W2766265212 cites W2063252903 @default.
- W2766265212 cites W2064145492 @default.
- W2766265212 cites W2065799563 @default.
- W2766265212 cites W2069347512 @default.
- W2766265212 cites W2074306827 @default.
- W2766265212 cites W2075729802 @default.
- W2766265212 cites W2082534286 @default.
- W2766265212 cites W2089827566 @default.
- W2766265212 cites W2107977954 @default.
- W2766265212 cites W2114200189 @default.
- W2766265212 cites W2114980337 @default.
- W2766265212 cites W2115054742 @default.
- W2766265212 cites W2123588904 @default.
- W2766265212 cites W2127788612 @default.
- W2766265212 cites W2129777487 @default.
- W2766265212 cites W2130673296 @default.
- W2766265212 cites W2132431231 @default.
- W2766265212 cites W2138732375 @default.
- W2766265212 cites W2141039922 @default.
- W2766265212 cites W2142161829 @default.
- W2766265212 cites W2143618521 @default.
- W2766265212 cites W2145918648 @default.
- W2766265212 cites W2147060678 @default.
- W2766265212 cites W2150611307 @default.
- W2766265212 cites W2162648910 @default.
- W2766265212 cites W2163592796 @default.
- W2766265212 cites W2164753308 @default.
- W2766265212 cites W2164946653 @default.
- W2766265212 cites W2166026513 @default.
- W2766265212 cites W2167092476 @default.
- W2766265212 cites W2168404690 @default.
- W2766265212 cites W2169175507 @default.
- W2766265212 cites W2186008338 @default.
- W2766265212 cites W2235405584 @default.
- W2766265212 cites W2238288150 @default.
- W2766265212 cites W2272134900 @default.
- W2766265212 cites W2292001892 @default.
- W2766265212 cites W2292214970 @default.
- W2766265212 cites W2321589388 @default.
- W2766265212 cites W2395507246 @default.
- W2766265212 cites W2404538383 @default.
- W2766265212 cites W2442085612 @default.
- W2766265212 cites W2510940971 @default.
- W2766265212 cites W2520810168 @default.
- W2766265212 cites W2549651109 @default.
- W2766265212 cites W2552037618 @default.
- W2766265212 cites W2554734803 @default.
- W2766265212 cites W2586890927 @default.
- W2766265212 cites W2602633586 @default.
- W2766265212 cites W2607221715 @default.
- W2766265212 cites W2607581659 @default.
- W2766265212 cites W2724698376 @default.
- W2766265212 cites W4232673372 @default.
- W2766265212 doi "https://doi.org/10.1002/ijc.31106" @default.
- W2766265212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29044514" @default.
- W2766265212 hasPublicationYear "2017" @default.
- W2766265212 type Work @default.
- W2766265212 sameAs 2766265212 @default.