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• W2768001808 abstract "Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in Cd40-/- mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed in excitatory and inhibitory neurons cultured from Cd40-/- mice and were rescued by soluble CD40. The changes in excitatory and inhibitory neurons cultured from Cd40-/- mice were mimicked in neurons of Cd40+/+ mice by treatment with soluble CD40L and were dependent on PKC-β and PKC-γ, respectively. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms." @default.
• W2768001808 created "2017-11-17" @default.
• W2768001808 creator A5029315678 @default.
• W2768001808 creator A5042455080 @default.
• W2768001808 date "2017-11-07" @default.
• W2768001808 modified "2023-10-16" @default.
• W2768001808 title "CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons" @default.
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• W2768001808 doi "https://doi.org/10.7554/elife.30442" @default.
• W2768001808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5687868" @default.
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