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- W2770829471 endingPage "781" @default.
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- W2770829471 abstract "Purpose: In the late 1990s, it had become clear that the long-standing paradigm for the action of radiation on living cells and organisms did not have sufficient power to explain the observed effects of low dose ionizing radiation. The purpose of this commentary is to examine the experiments that lead up to the modification of the classic paradigm consequent on these observations, their historical precedents, and the development of our understanding of the role of epigenetics in low dose radiation effects.Results and conclusions: We discuss how parallel advances in epigenetics from developmental biology and cancer studies, and the discovery of epigenetic modifications of chromatin, such as DNA methylation, impacted on the development of an epigenetic paradigm for low dose effects. We also assess the impact of technology development in supporting the paradigm shift. We then examine recent accumulated data on epigenetic modification in response to irradiation since that shift took place, and identify areas where bringing together data from developmental biology and cancer might answer some of the paradoxes and contradictions in this data. We predict that further paradigm shifts are imminent." @default.
- W2770829471 created "2017-12-04" @default.
- W2770829471 creator A5059588755 @default.
- W2770829471 creator A5060426126 @default.
- W2770829471 date "2017-12-01" @default.
- W2770829471 modified "2023-09-25" @default.
- W2770829471 title "Evolving paradigms for the biological response to low dose ionizing radiation; the role of epigenetics" @default.
- W2770829471 cites W1450170229 @default.
- W2770829471 cites W1483688385 @default.
- W2770829471 cites W1519629411 @default.
- W2770829471 cites W1520316733 @default.
- W2770829471 cites W1916834316 @default.
- W2770829471 cites W1965262464 @default.
- W2770829471 cites W1965675196 @default.
- W2770829471 cites W1966082965 @default.
- W2770829471 cites W1966413695 @default.
- W2770829471 cites W1968029748 @default.
- W2770829471 cites W1968900034 @default.
- W2770829471 cites W1971708895 @default.
- W2770829471 cites W1974101557 @default.
- W2770829471 cites W1974126918 @default.
- W2770829471 cites W1975749767 @default.
- W2770829471 cites W1976935056 @default.
- W2770829471 cites W1977373878 @default.
- W2770829471 cites W1978386737 @default.
- W2770829471 cites W1980913212 @default.
- W2770829471 cites W1980920372 @default.
- W2770829471 cites W1981015651 @default.
- W2770829471 cites W1981350331 @default.
- W2770829471 cites W1983259076 @default.
- W2770829471 cites W1988001018 @default.
- W2770829471 cites W1989416640 @default.
- W2770829471 cites W1993663855 @default.
- W2770829471 cites W1995878525 @default.
- W2770829471 cites W1997427906 @default.
- W2770829471 cites W1997665714 @default.
- W2770829471 cites W1998458666 @default.
- W2770829471 cites W1998639983 @default.
- W2770829471 cites W1998976898 @default.
- W2770829471 cites W1999027330 @default.
- W2770829471 cites W1999572884 @default.
- W2770829471 cites W2000819178 @default.
- W2770829471 cites W2001952649 @default.
- W2770829471 cites W2002664587 @default.
- W2770829471 cites W2004595473 @default.
- W2770829471 cites W2006290914 @default.
- W2770829471 cites W2007214149 @default.
- W2770829471 cites W2009786683 @default.
- W2770829471 cites W2009940298 @default.
- W2770829471 cites W2011565438 @default.
- W2770829471 cites W2012703624 @default.
- W2770829471 cites W2017662317 @default.
- W2770829471 cites W2019211320 @default.
- W2770829471 cites W2025031749 @default.
- W2770829471 cites W2026297273 @default.
- W2770829471 cites W2028483534 @default.
- W2770829471 cites W2028485852 @default.
- W2770829471 cites W2029299113 @default.
- W2770829471 cites W2029868343 @default.
- W2770829471 cites W2030352860 @default.
- W2770829471 cites W2034158880 @default.
- W2770829471 cites W2036048970 @default.
- W2770829471 cites W2037621441 @default.
- W2770829471 cites W2038871272 @default.
- W2770829471 cites W2041483656 @default.
- W2770829471 cites W2041674913 @default.
- W2770829471 cites W2043500928 @default.
- W2770829471 cites W2044505200 @default.
- W2770829471 cites W2047313692 @default.
- W2770829471 cites W2051406511 @default.
- W2770829471 cites W2052389197 @default.
- W2770829471 cites W2054749775 @default.
- W2770829471 cites W2055913006 @default.
- W2770829471 cites W2061108324 @default.
- W2770829471 cites W2064527197 @default.
- W2770829471 cites W2067327293 @default.
- W2770829471 cites W2068449224 @default.
- W2770829471 cites W2069150999 @default.
- W2770829471 cites W2069717852 @default.
- W2770829471 cites W2072255720 @default.
- W2770829471 cites W2079426778 @default.
- W2770829471 cites W2081403346 @default.
- W2770829471 cites W2084203180 @default.
- W2770829471 cites W2085441698 @default.
- W2770829471 cites W2088425357 @default.
- W2770829471 cites W2088717715 @default.
- W2770829471 cites W2089804431 @default.
- W2770829471 cites W2094558289 @default.
- W2770829471 cites W2096196036 @default.
- W2770829471 cites W2096446242 @default.
- W2770829471 cites W2096459936 @default.
- W2770829471 cites W2100489386 @default.
- W2770829471 cites W2101331356 @default.
- W2770829471 cites W2102863902 @default.
- W2770829471 cites W2106340111 @default.
- W2770829471 cites W2107516043 @default.
- W2770829471 cites W2109126550 @default.
- W2770829471 cites W2112560472 @default.