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- W2775307310 abstract "Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional Rb-positive cancers might benefit from these agents. No systematic survey to compare relative sensitivities across tumor types and define molecular determinants of response has been described. We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describe a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer. The results suggest multiple additional classes of cancer that may benefit from CDK4/6-inhibiting drugs such as abemaciclib." @default.
- W2775307310 created "2017-12-22" @default.
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- W2775307310 date "2017-12-01" @default.
- W2775307310 modified "2023-10-14" @default.
- W2775307310 title "Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib" @default.
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- W2775307310 doi "https://doi.org/10.1016/j.ccell.2017.11.006" @default.
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- W2775307310 hasPublicationYear "2017" @default.
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