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- W2775387645 endingPage "241" @default.
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- W2775387645 abstract "Architecture of the TRPM subfamily Transient receptor potential melastatin (TRPM) ion channels constitute the largest TRP subfamily and are involved in many physiological processes. TRPM8 is the primary cold and menthol sensor, and TRPM4 is associated with cardiovascular disorders. Yin et al. and Autzen et al. shed light on the general architecture of the TRPM subfamily by solving the structures of TRPM8 and TRPM4, respectively (see the Perspective by Bae et al. ). The three-layered architecture of the TRPM8 channel provides the framework for understanding the mechanisms of cold and menthol sensing. The two distinct closed states of TRPM4, with and without calcium, reveal a calcium-binding site and calcium-binding-induced conformational changes. Science , this issue p. 237 , p. 228 ; see also p. 160" @default.
- W2775387645 created "2017-12-22" @default.
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- W2775387645 date "2018-01-12" @default.
- W2775387645 modified "2023-10-18" @default.
- W2775387645 title "Structure of the cold- and menthol-sensing ion channel TRPM8" @default.
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- W2775387645 doi "https://doi.org/10.1126/science.aan4325" @default.
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