FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796249140> ?p ?o ?g. }

• W2796249140 abstract "Most high grade serous ovarian carcinomas (HGSC) arise from Serous Tubal Intraepithelial Carcinoma (STIC) lesions in the distal end of the fallopian tube (FT). FT secretory cells become malignant by accumulating genomic aberrations over 6 to 7 years before seeding of the ovarian surface, with rapid tumor dissemination to other abdominal structures thereafter. It remains unclear how nascent malignant cells leave the FT to colonize the ovary. This report provides evidence that the L1 cell adhesion molecule (L1CAM) contributes to the ability of transformed FT secretory cells (FTSEC) to detach from the tube, survive under anchorage-independent conditions, and seed the ovarian surface. L1CAM was highly expressed on the apical surface of STIC lesions and contributed to ovarian colonization by upregulating integrin and fibronectin in malignant cells and activating the AKT and ERK pathways. These changes increased cell survival under ultralow attachment conditions that mimic transit from the FT to the ovary. To study metastasis to the ovary, we developed a tumor ovary coculture model. We showed that L1CAM expression was important for FT cells to invade the ovary as a cohesive group. Our results indicate that in the early stages of HGSC development, transformed FTSECs disseminate from the FT to the ovary in L1CAM dependent manner." @default.
• W2796249140 created "2018-04-13" @default.
• W2796249140 creator A5017879897 @default.
• W2796249140 creator A5021133612 @default.
• W2796249140 creator A5048102923 @default.
• W2796249140 creator A5065593057 @default.
• W2796249140 creator A5073209814 @default.
• W2796249140 creator A5080054376 @default.
• W2796249140 creator A5080651733 @default.
• W2796249140 creator A5086354357 @default.
• W2796249140 creator A5086475860 @default.
• W2796249140 creator A5086687735 @default.
• W2796249140 creator A5087999591 @default.
• W2796249140 date "2018-03-02" @default.
• W2796249140 modified "2023-09-22" @default.
• W2796249140 title "Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis" @default.
• W2796249140 cites W168898604 @default.
• W2796249140 cites W1757407923 @default.
• W2796249140 cites W1819122594 @default.
• W2796249140 cites W1885963046 @default.
• W2796249140 cites W1974756790 @default.
• W2796249140 cites W1978641793 @default.
• W2796249140 cites W1979760206 @default.
• W2796249140 cites W1983172399 @default.
• W2796249140 cites W1985789005 @default.
• W2796249140 cites W1986010151 @default.
• W2796249140 cites W2005071828 @default.
• W2796249140 cites W2013107316 @default.
• W2796249140 cites W2019318549 @default.
• W2796249140 cites W2022991180 @default.
• W2796249140 cites W2025880272 @default.
• W2796249140 cites W2028275873 @default.
• W2796249140 cites W2039313209 @default.
• W2796249140 cites W2042384810 @default.
• W2796249140 cites W2056087352 @default.
• W2796249140 cites W2071014344 @default.
• W2796249140 cites W2071356736 @default.
• W2796249140 cites W2071855640 @default.
• W2796249140 cites W2075711878 @default.
• W2796249140 cites W2098585582 @default.
• W2796249140 cites W2123696077 @default.
• W2796249140 cites W2133736395 @default.
• W2796249140 cites W2137750805 @default.
• W2796249140 cites W2147478966 @default.
• W2796249140 cites W2148014174 @default.
• W2796249140 cites W2150823776 @default.
• W2796249140 cites W2157549466 @default.
• W2796249140 cites W2158485828 @default.
• W2796249140 cites W2160080625 @default.
• W2796249140 cites W2163943857 @default.
• W2796249140 cites W2167936961 @default.
• W2796249140 cites W2168645747 @default.
• W2796249140 cites W2463378434 @default.
• W2796249140 cites W2528092098 @default.
• W2796249140 cites W2557243447 @default.
• W2796249140 cites W2572326611 @default.
• W2796249140 cites W2622604003 @default.
• W2796249140 cites W2764321027 @default.
• W2796249140 cites W2767122952 @default.
• W2796249140 doi "https://doi.org/10.1101/270785" @default.
• W2796249140 hasPublicationYear "2018" @default.
• W2796249140 type Work @default.
• W2796249140 sameAs 2796249140 @default.
• W2796249140 citedByCount "5" @default.
• W2796249140 countsByYear W27962491402020 @default.
• W2796249140 countsByYear W27962491402021 @default.
• W2796249140 crossrefType "posted-content" @default.
• W2796249140 hasAuthorship W2796249140A5017879897 @default.
• W2796249140 hasAuthorship W2796249140A5021133612 @default.
• W2796249140 hasAuthorship W2796249140A5048102923 @default.
• W2796249140 hasAuthorship W2796249140A5065593057 @default.
• W2796249140 hasAuthorship W2796249140A5073209814 @default.
• W2796249140 hasAuthorship W2796249140A5080054376 @default.
• W2796249140 hasAuthorship W2796249140A5080651733 @default.
• W2796249140 hasAuthorship W2796249140A5086354357 @default.
• W2796249140 hasAuthorship W2796249140A5086475860 @default.
• W2796249140 hasAuthorship W2796249140A5086687735 @default.
• W2796249140 hasAuthorship W2796249140A5087999591 @default.
• W2796249140 hasBestOaLocation W27962491401 @default.
• W2796249140 hasConcept C105702510 @default.
• W2796249140 hasConcept C121608353 @default.
• W2796249140 hasConcept C134018914 @default.
• W2796249140 hasConcept C142724271 @default.
• W2796249140 hasConcept C150173356 @default.
• W2796249140 hasConcept C2775883341 @default.
• W2796249140 hasConcept C2776726509 @default.
• W2796249140 hasConcept C2777632260 @default.
• W2796249140 hasConcept C2778324911 @default.
• W2796249140 hasConcept C2779013556 @default.
• W2796249140 hasConcept C2780427987 @default.
• W2796249140 hasConcept C3019054536 @default.
• W2796249140 hasConcept C502942594 @default.
• W2796249140 hasConcept C54355233 @default.
• W2796249140 hasConcept C71924100 @default.
• W2796249140 hasConcept C86803240 @default.
• W2796249140 hasConceptScore W2796249140C105702510 @default.
• W2796249140 hasConceptScore W2796249140C121608353 @default.
• W2796249140 hasConceptScore W2796249140C134018914 @default.
• W2796249140 hasConceptScore W2796249140C142724271 @default.
• W2796249140 hasConceptScore W2796249140C150173356 @default.

• next