Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797737805> ?p ?o ?g. }
- W2797737805 endingPage "387" @default.
- W2797737805 startingPage "377" @default.
- W2797737805 abstract "Splenic tyrosine kinase (SYK) is a non-receptor tyrosine kinase. It is important for downstream signaling from several cell surface receptors, including Fc receptors, complement receptors and integrins. SYK can have either oncogenic or tumor suppressor activity in human malignancies. Recent studies suggest that SYK inhibition may have an antileukemic effect in human acute myeloid leukemia (AML).Relevant publications were identified through literature searches in the PubMed database. We searched for (i) original articles describing the results from clinical studies of SYK inhibition; (ii) published articles describing the importance of SYK in human malignancies, especially AML.SYK is important for the downstream signaling from several cell surface receptors. There is also a crosstalk between SYK and signaling initiated through ligation of Toll like receptors, and SYK is thereby linked with the NFκB mediated transcriptional regulation. SYK activation will also influence PI3K-Akt-mTOR signaling. Several of these signaling events are important for survival and proliferation of primary human AML cells. In the present review we describe and discuss the role of SYK in human AML, and these data suggest that SYK inhibition is a possible therapeutic strategy in human AML." @default.
- W2797737805 created "2018-04-24" @default.
- W2797737805 creator A5021294750 @default.
- W2797737805 creator A5028830320 @default.
- W2797737805 creator A5052228012 @default.
- W2797737805 creator A5053862074 @default.
- W2797737805 creator A5069016700 @default.
- W2797737805 date "2018-04-03" @default.
- W2797737805 modified "2023-09-30" @default.
- W2797737805 title "Splenic tyrosine kinase (SYK) inhibitors and their possible use in acute myeloid leukemia" @default.
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