Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801496825> ?p ?o ?g. }
- W2801496825 endingPage "92" @default.
- W2801496825 startingPage "51" @default.
- W2801496825 abstract "Activation-induced cytidine deaminase (AID) expression in the germinal center response drives the immunoglobulin class-switch recombination and V(D)J hypermutation necessary for efficacious, high-affinity antibody responses. That AID is expressed in developing lymphocytes is less well known, but represents an evolutionarily conserved pattern of lymphocyte development that is represented in all vertebrate species. Here we review the role of early, developmentally regulated AID expression in mice and humans and its role in establishing the first B-cell tolerance checkpoint. This newly recognized component of central tolerance requires coordinate signaling by poly- or autoreactive B-cell antigen receptors and endosomal Toll-like receptors. These signals synergize to upregulate AID expression in immature and transitional B cells to levels that approach that of germinal center B cells with the result of caspase 3-mediated cell death. In this review, we discuss the origins and mechanism of this interesting collaboration between adaptive and innate receptors to purge the primary B-cell repertoire of self-reactivity and how it may be related to receptor editing, the other major mechanism for central tolerance." @default.
- W2801496825 created "2018-05-17" @default.
- W2801496825 creator A5005679572 @default.
- W2801496825 creator A5065001474 @default.
- W2801496825 creator A5071215510 @default.
- W2801496825 date "2018-01-01" @default.
- W2801496825 modified "2023-09-24" @default.
- W2801496825 title "The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID" @default.
- W2801496825 cites W129650649 @default.
- W2801496825 cites W1436270903 @default.
- W2801496825 cites W1490561727 @default.
- W2801496825 cites W1533361575 @default.
- W2801496825 cites W1559912818 @default.
- W2801496825 cites W1591766096 @default.
- W2801496825 cites W1606782385 @default.
- W2801496825 cites W1709757466 @default.
- W2801496825 cites W1780006609 @default.
- W2801496825 cites W1810947597 @default.
- W2801496825 cites W1832366659 @default.
- W2801496825 cites W1834505123 @default.
- W2801496825 cites W1927946859 @default.
- W2801496825 cites W1948212455 @default.
- W2801496825 cites W1966566722 @default.
- W2801496825 cites W1966851529 @default.
- W2801496825 cites W1966949480 @default.
- W2801496825 cites W1967407054 @default.
- W2801496825 cites W1968757041 @default.
- W2801496825 cites W1969156908 @default.
- W2801496825 cites W1970116602 @default.
- W2801496825 cites W1971894480 @default.
- W2801496825 cites W1973389611 @default.
- W2801496825 cites W1976223017 @default.
- W2801496825 cites W1979497249 @default.
- W2801496825 cites W1980193047 @default.
- W2801496825 cites W1980994198 @default.
- W2801496825 cites W1982289564 @default.
- W2801496825 cites W1983664778 @default.
- W2801496825 cites W1985985051 @default.
- W2801496825 cites W1986088199 @default.
- W2801496825 cites W1989365647 @default.
- W2801496825 cites W1989556124 @default.
- W2801496825 cites W1994106597 @default.
- W2801496825 cites W1995025510 @default.
- W2801496825 cites W2002043709 @default.
- W2801496825 cites W2002632348 @default.
- W2801496825 cites W2004465286 @default.
- W2801496825 cites W2008073080 @default.
- W2801496825 cites W2008489452 @default.
- W2801496825 cites W2008546779 @default.
- W2801496825 cites W2009432831 @default.
- W2801496825 cites W2014334082 @default.
- W2801496825 cites W2014549199 @default.
- W2801496825 cites W2015392285 @default.
- W2801496825 cites W2015848842 @default.
- W2801496825 cites W2017533703 @default.
- W2801496825 cites W2017712914 @default.
- W2801496825 cites W2021893136 @default.
- W2801496825 cites W2025412364 @default.
- W2801496825 cites W2025591085 @default.
- W2801496825 cites W2025640975 @default.
- W2801496825 cites W2026634264 @default.
- W2801496825 cites W2026925153 @default.
- W2801496825 cites W2030816309 @default.
- W2801496825 cites W2034271713 @default.
- W2801496825 cites W2037024044 @default.
- W2801496825 cites W2037706042 @default.
- W2801496825 cites W2038638188 @default.
- W2801496825 cites W2038706764 @default.
- W2801496825 cites W2039919570 @default.
- W2801496825 cites W2041349460 @default.
- W2801496825 cites W2041524501 @default.
- W2801496825 cites W2041652998 @default.
- W2801496825 cites W2043631671 @default.
- W2801496825 cites W2046052383 @default.
- W2801496825 cites W2047554700 @default.
- W2801496825 cites W2047865956 @default.
- W2801496825 cites W2048180523 @default.
- W2801496825 cites W2049824360 @default.
- W2801496825 cites W2050649251 @default.
- W2801496825 cites W2051087428 @default.
- W2801496825 cites W2051113765 @default.
- W2801496825 cites W2051729351 @default.
- W2801496825 cites W2052551815 @default.
- W2801496825 cites W2056265881 @default.
- W2801496825 cites W2056334527 @default.
- W2801496825 cites W2057800919 @default.
- W2801496825 cites W2057902325 @default.
- W2801496825 cites W2059318379 @default.
- W2801496825 cites W2060351820 @default.
- W2801496825 cites W2060618478 @default.
- W2801496825 cites W2064421628 @default.
- W2801496825 cites W2064811345 @default.
- W2801496825 cites W2065152431 @default.
- W2801496825 cites W2068378281 @default.
- W2801496825 cites W2070216538 @default.
- W2801496825 cites W2072320300 @default.
- W2801496825 cites W2074064125 @default.
- W2801496825 cites W2076198413 @default.