FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801705870> ?p ?o ?g. }

• W2801705870 endingPage "721" @default.
• W2801705870 startingPage "707" @default.
• W2801705870 abstract "This study aimed to assess clinicopathologic features of transactive response DNA-binding protein of 43 kDa (TDP-43) pathology and its risk factors in multiple system atrophy (MSA).Paraffin-embedded sections of the amygdala and basal forebrain from 186 autopsy-confirmed MSA cases were screened with immunohistochemistry for phospho-TDP-43. In cases having TDP-43 pathology, additional brain regions were assessed. Immunohistochemical and immunofluorescence double-staining and immunogold electron microscopy (IEM) were performed to evaluate colocalization of TDP-43 and α-synuclein. Genetic risk factors for TDP-43 pathology were also analysed.Immunohistochemistry showed various morphologies of TDP-43 pathology in 13 cases (7%), such as subpial astrocytic inclusions, neuronal inclusions, dystrophic neurites, perivascular inclusions and glial cytoplasmic inclusions (GCIs). Multivariable logistic regression models revealed that only advanced age, but not concurrent Alzheimer's disease, argyrophilic grain disease or hippocampal sclerosis, was an independent risk factor for TDP-43 pathology in MSA (OR: 1.11, 95% CI: 1.04-1.19, P = 0.002). TDP-43 pathology was restricted to the amygdala in eight cases and extended to the hippocampus in two cases. The remaining three cases had widespread TDP-43 pathology. Immunohistochemical and immunofluorescence double-staining and IEM revealed colocalization of α-synuclein and TDP-43 in GCIs with granule-coated filaments. Pilot genetic studies failed to show associations between risk variants of TMEM106B or GRN and TDP-43 pathology.TDP-43 pathology is rare in MSA and occurs mainly in the medial temporal lobe. Advanced age is a risk factor for TDP-43 pathology in MSA. Colocalization of TDP-43 and α-synuclein in GCIs suggests possible direct interaction between the two molecules." @default.
• W2801705870 created "2018-05-17" @default.
• W2801705870 creator A5009533777 @default.
• W2801705870 creator A5009821300 @default.
• W2801705870 creator A5060236950 @default.
• W2801705870 creator A5073233893 @default.
• W2801705870 creator A5074593768 @default.
• W2801705870 date "2018-05-09" @default.
• W2801705870 modified "2023-09-29" @default.
• W2801705870 title "TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions" @default.
• W2801705870 cites W1519095619 @default.
• W2801705870 cites W1737594935 @default.
• W2801705870 cites W1873640461 @default.
• W2801705870 cites W1921675910 @default.
• W2801705870 cites W1931319403 @default.
• W2801705870 cites W1967823816 @default.
• W2801705870 cites W1968324269 @default.
• W2801705870 cites W1969040413 @default.
• W2801705870 cites W1975860260 @default.
• W2801705870 cites W1976537088 @default.
• W2801705870 cites W1978122964 @default.
• W2801705870 cites W1979060890 @default.
• W2801705870 cites W1995276702 @default.
• W2801705870 cites W2002506451 @default.
• W2801705870 cites W2003618511 @default.
• W2801705870 cites W2008234948 @default.
• W2801705870 cites W2009710550 @default.
• W2801705870 cites W2012765198 @default.
• W2801705870 cites W2014670147 @default.
• W2801705870 cites W2027177575 @default.
• W2801705870 cites W2037214298 @default.
• W2801705870 cites W2044184260 @default.
• W2801705870 cites W2047668311 @default.
• W2801705870 cites W2049474063 @default.
• W2801705870 cites W2052742260 @default.
• W2801705870 cites W2059860906 @default.
• W2801705870 cites W2059980851 @default.
• W2801705870 cites W2065140753 @default.
• W2801705870 cites W2068744836 @default.
• W2801705870 cites W2074712798 @default.
• W2801705870 cites W2075234789 @default.
• W2801705870 cites W2090048744 @default.
• W2801705870 cites W2092646825 @default.
• W2801705870 cites W2102901087 @default.
• W2801705870 cites W2115672510 @default.
• W2801705870 cites W2121960517 @default.
• W2801705870 cites W2125948889 @default.
• W2801705870 cites W2128228199 @default.
• W2801705870 cites W2128474176 @default.
• W2801705870 cites W2136057227 @default.
• W2801705870 cites W2136305293 @default.
• W2801705870 cites W2149464851 @default.
• W2801705870 cites W2155299862 @default.
• W2801705870 cites W2163955717 @default.
• W2801705870 cites W2164435689 @default.
• W2801705870 cites W2168930923 @default.
• W2801705870 cites W2196099055 @default.
• W2801705870 cites W2279634262 @default.
• W2801705870 cites W2300806746 @default.
• W2801705870 cites W2477635431 @default.
• W2801705870 cites W2516101459 @default.
• W2801705870 cites W2525541800 @default.
• W2801705870 cites W2555935045 @default.
• W2801705870 cites W2563474251 @default.
• W2801705870 cites W2591717879 @default.
• W2801705870 cites W2736212172 @default.
• W2801705870 cites W2743281712 @default.
• W2801705870 cites W2753262270 @default.
• W2801705870 cites W32398059 @default.
• W2801705870 doi "https://doi.org/10.1111/nan.12485" @default.
• W2801705870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191374" @default.
• W2801705870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29660838" @default.
• W2801705870 hasPublicationYear "2018" @default.
• W2801705870 type Work @default.
• W2801705870 sameAs 2801705870 @default.
• W2801705870 citedByCount "36" @default.
• W2801705870 countsByYear W28017058702018 @default.
• W2801705870 countsByYear W28017058702019 @default.
• W2801705870 countsByYear W28017058702020 @default.
• W2801705870 countsByYear W28017058702021 @default.
• W2801705870 countsByYear W28017058702022 @default.
• W2801705870 countsByYear W28017058702023 @default.
• W2801705870 crossrefType "journal-article" @default.
• W2801705870 hasAuthorship W2801705870A5009533777 @default.
• W2801705870 hasAuthorship W2801705870A5009821300 @default.
• W2801705870 hasAuthorship W2801705870A5060236950 @default.
• W2801705870 hasAuthorship W2801705870A5073233893 @default.
• W2801705870 hasAuthorship W2801705870A5074593768 @default.
• W2801705870 hasBestOaLocation W28017058702 @default.
• W2801705870 hasConcept C142724271 @default.
• W2801705870 hasConcept C169760540 @default.
• W2801705870 hasConcept C204232928 @default.
• W2801705870 hasConcept C2777597344 @default.
• W2801705870 hasConcept C2778186239 @default.
• W2801705870 hasConcept C2779134260 @default.
• W2801705870 hasConcept C2780130745 @default.
• W2801705870 hasConcept C2781099131 @default.
• W2801705870 hasConcept C2994092119 @default.

• next