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- W2806121054 abstract "Aim: Using a simple modification on a previously reported synthetic route, 3-benzyl(phenethyl)-2-thioxobenzo[g]quinazolin-4(3H)-ones (1 and 2) were synthesized with high yields. Further transformation of 1 and 2 produced derivatives 3-26, which were structurally characterized based on NMR and MS data, and their in vitro α-glucosidase inhibitory activity was evaluated using Baker's yeast α-glucosidase enzyme. Results: Compounds 2, 4, 8, 12 and 20 exhibited the highest activity (IC 50 = 69.20, 59.60, 49.40, 50.20 and 83.20 μM, respectively) compared with the standard acarbose (IC 50 = 143.54 μM). Conclusion: A new class of potent α-glucosidase inhibitors was identified, and the molecular docking predicted plausible binding interaction of the targets in the binding pocket of α-glucosidase and rationalized the structure–activity relationship (SARs) of the target compounds." @default.
- W2806121054 created "2018-06-13" @default.
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- W2806121054 date "2018-08-01" @default.
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- W2806121054 title "3-Benzyl(phenethyl)-2-thioxobenzo[<i>g</i>]quinazolines as a new class of potent α-glucosidase inhibitors: synthesis and molecular docking study" @default.
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- W2806121054 doi "https://doi.org/10.4155/fmc-2018-0141" @default.
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