FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806670267> ?p ?o ?g. }

• W2806670267 endingPage "1020" @default.
• W2806670267 startingPage "1011" @default.
• W2806670267 abstract "Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry María Elena Rodríguez González-Herrero,1 Marcos Ruiz,1 Francisco Javier López Román,2 José María Marín Sánchez,1 Joan Carles Domingo3 1Service of Ophthalmology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain; 2Department of Exercise Physiology, Faculty of Health Sciences, San Antonio Catholic University of Murcia (UCAM), Murcia, Spain; 3Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain Objective: There is little evidence of real-life outcomes of dietary supplementation with high-dose docosahexaenoic acid (DHA) and carotenoids in patients with diabetic retinopathy (DR). We assessed the effect of supplementation with DHA triglyceride (1,050 mg/d) + xanthophyll carotenoid multivitamin on macular function in nonproliferative DR.Methods: Asymptomatic patients with nonproliferative DR were included in a prospective controlled study and assigned (1:1) to the DHA supplementation group or the control group. Macular sensitivity and macular integrity area were the main outcome measures. Functional vision measures (macular function [MAIA™ CenterVue], best-corrected visual acuity), structural retinal measures (central subfield macular thickness), and biochemical parameters (plasma total antioxidant capacity, DHA content of the erythrocyte membrane, and plasma IL-6) were evaluated at baseline and after 45 and 90 days of DHA supplementation.Results: The study included 24 patients (48 eyes) (12 patients, 24 eyes in each group). Baseline clinical characteristics of patients in both groups were similar. Macular sensitivity increased from a mean (SD) of 25.9 (2.4) dB at baseline to 27.3 (2.3) dB at 90 days (P=0.030) in the DHA group only (between-group differences P<0.19). The macular integrity index decreased from 71.2 (33.2) at baseline to 63.5 (36.4) at 45 days and to 51.6 (35.9) at 90 days (P=0.002) in the DHA group only (between-group differences P<0.05). Best-corrected visual acuity and central subfield macular thickness did not vary significantly in any of the comparisons and in none of the groups. DHA content of erythrocyte membrane and total antioxidant capacity levels increased significantly only in the DHA group. Plasma IL-6 levels decreased significantly only in the DHA group.Conclusion: In an early stage of DR, supplementation with high-dose DHA plus xanthophyll carotenoid multivitamin during 90 days was associated with a progressive and significant improvement of macular function measured by microperimetry. Biochemical changes supported the effect of DHA. Keywords: microperimetry, nonproliferative diabetic retinopathy, macular function, docosahexaenoic acid, macular sensitivity, macular integrity index, prospective controlled study" @default.
• W2806670267 created "2018-06-13" @default.
• W2806670267 creator A5000143857 @default.
• W2806670267 creator A5012533826 @default.
• W2806670267 creator A5045562166 @default.
• W2806670267 creator A5066904879 @default.
• W2806670267 creator A5078917733 @default.
• W2806670267 date "2018-05-01" @default.
• W2806670267 modified "2023-09-24" @default.
• W2806670267 title "Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry" @default.
• W2806670267 cites W1530400404 @default.
• W2806670267 cites W1739691545 @default.
• W2806670267 cites W1841077109 @default.
• W2806670267 cites W1970668118 @default.
• W2806670267 cites W1974471174 @default.
• W2806670267 cites W1993063275 @default.
• W2806670267 cites W1996954936 @default.
• W2806670267 cites W1998707239 @default.
• W2806670267 cites W2005457087 @default.
• W2806670267 cites W2006337254 @default.
• W2806670267 cites W2006572395 @default.
• W2806670267 cites W2008213605 @default.
• W2806670267 cites W2013681920 @default.
• W2806670267 cites W2013737946 @default.
• W2806670267 cites W2018466311 @default.
• W2806670267 cites W2031740343 @default.
• W2806670267 cites W2032643064 @default.
• W2806670267 cites W2042212286 @default.
• W2806670267 cites W2048661776 @default.
• W2806670267 cites W2050769791 @default.
• W2806670267 cites W2052469649 @default.
• W2806670267 cites W2054448290 @default.
• W2806670267 cites W2063412891 @default.
• W2806670267 cites W2063880592 @default.
• W2806670267 cites W2067328080 @default.
• W2806670267 cites W2076232924 @default.
• W2806670267 cites W2076304999 @default.
• W2806670267 cites W2095558585 @default.
• W2806670267 cites W2096060458 @default.
• W2806670267 cites W2097958521 @default.
• W2806670267 cites W2099020618 @default.
• W2806670267 cites W2104285446 @default.
• W2806670267 cites W2107445190 @default.
• W2806670267 cites W2111143090 @default.
• W2806670267 cites W2111665358 @default.
• W2806670267 cites W2142849241 @default.
• W2806670267 cites W2143659187 @default.
• W2806670267 cites W2159449658 @default.
• W2806670267 cites W2160241739 @default.
• W2806670267 cites W2167206966 @default.
• W2806670267 cites W2169088593 @default.
• W2806670267 cites W2172216858 @default.
• W2806670267 cites W2175077763 @default.
• W2806670267 cites W2175704762 @default.
• W2806670267 cites W2211467290 @default.
• W2806670267 cites W2260226868 @default.
• W2806670267 cites W2296439120 @default.
• W2806670267 cites W2398770321 @default.
• W2806670267 cites W2414104000 @default.
• W2806670267 cites W2489455328 @default.
• W2806670267 cites W2513562413 @default.
• W2806670267 cites W2540939961 @default.
• W2806670267 cites W2581527741 @default.
• W2806670267 cites W2587462790 @default.
• W2806670267 cites W2603168364 @default.
• W2806670267 cites W2604666287 @default.
• W2806670267 cites W2620565698 @default.
• W2806670267 cites W27647494 @default.
• W2806670267 cites W2793245808 @default.
• W2806670267 cites W4210963746 @default.
• W2806670267 cites W4211205882 @default.
• W2806670267 cites W4299436089 @default.
• W2806670267 doi "https://doi.org/10.2147/opth.s157635" @default.
• W2806670267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5983010" @default.
• W2806670267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29881256" @default.
• W2806670267 hasPublicationYear "2018" @default.
• W2806670267 type Work @default.
• W2806670267 sameAs 2806670267 @default.
• W2806670267 citedByCount "20" @default.
• W2806670267 countsByYear W28066702672018 @default.
• W2806670267 countsByYear W28066702672019 @default.
• W2806670267 countsByYear W28066702672020 @default.
• W2806670267 countsByYear W28066702672021 @default.
• W2806670267 countsByYear W28066702672022 @default.
• W2806670267 countsByYear W28066702672023 @default.
• W2806670267 crossrefType "journal-article" @default.
• W2806670267 hasAuthorship W2806670267A5000143857 @default.
• W2806670267 hasAuthorship W2806670267A5012533826 @default.
• W2806670267 hasAuthorship W2806670267A5045562166 @default.
• W2806670267 hasAuthorship W2806670267A5066904879 @default.
• W2806670267 hasAuthorship W2806670267A5078917733 @default.
• W2806670267 hasBestOaLocation W28066702671 @default.
• W2806670267 hasConcept C118487528 @default.
• W2806670267 hasConcept C126322002 @default.
• W2806670267 hasConcept C134018914 @default.
• W2806670267 hasConcept C188816634 @default.
• W2806670267 hasConcept C19038510 @default.
• W2806670267 hasConcept C2776391266 @default.

• next