FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807742933> ?p ?o ?g. }

• W2807742933 endingPage "1409" @default.
• W2807742933 startingPage "1398" @default.
• W2807742933 abstract "Although MEK blockade has been highlighted as a promising antitumor drug, it has poor clinical efficacy in KRAS mutant colorectal cancer (CRC). Several feedback systems have been described in which inhibition of one intracellular pathway leads to activation of a parallel signaling pathway, thereby decreasing the effectiveness of single-MEK targeted therapies. Here, we investigated a bypass mechanism of resistance to MEK inhibition in KRAS CRC. We found that KRAS mutant CRC cells with refametinib, MEK inhibitor, induced MIF secretion and resulted in activation of STAT3 and MAPK. MIF knockdown by siRNA restored sensitivity to refametinib in KRAS mutant cells. In addition, combination with refametinib and 4-IPP, a MIF inhibitor, effectively reduced the activity of STAT3 and MAPK, more than single-agent treatment. As a result, combined therapy was found to exhibit a synergistic growth inhibitory effect against refametinib-resistant cells by inhibition of MIF activation. These results reveal that MIF-induced STAT3 and MAPK activation evoked an intrinsic resistance to refametinib. Our results provide the basis for a rational combination strategy against KRAS mutant colorectal cancers, predicated on the understanding of cross talk between the MEK and MIF pathways." @default.
• W2807742933 created "2018-06-21" @default.
• W2807742933 creator A5016777122 @default.
• W2807742933 creator A5020476074 @default.
• W2807742933 creator A5046993341 @default.
• W2807742933 creator A5052037513 @default.
• W2807742933 creator A5052823826 @default.
• W2807742933 creator A5053123311 @default.
• W2807742933 creator A5053990271 @default.
• W2807742933 creator A5062080961 @default.
• W2807742933 date "2018-07-11" @default.
• W2807742933 modified "2023-10-09" @default.
• W2807742933 title "Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells" @default.
• W2807742933 cites W1601681275 @default.
• W2807742933 cites W1773617281 @default.
• W2807742933 cites W1864827749 @default.
• W2807742933 cites W1966011301 @default.
• W2807742933 cites W1971380103 @default.
• W2807742933 cites W1974981405 @default.
• W2807742933 cites W1975155171 @default.
• W2807742933 cites W1977336393 @default.
• W2807742933 cites W1979455711 @default.
• W2807742933 cites W1984262875 @default.
• W2807742933 cites W1993738876 @default.
• W2807742933 cites W2001067765 @default.
• W2807742933 cites W2001737701 @default.
• W2807742933 cites W2033042382 @default.
• W2807742933 cites W2044433744 @default.
• W2807742933 cites W2047308155 @default.
• W2807742933 cites W2050206485 @default.
• W2807742933 cites W2065486105 @default.
• W2807742933 cites W2070686081 @default.
• W2807742933 cites W2077945404 @default.
• W2807742933 cites W2080686146 @default.
• W2807742933 cites W2089686819 @default.
• W2807742933 cites W2097073373 @default.
• W2807742933 cites W2099044540 @default.
• W2807742933 cites W2102365935 @default.
• W2807742933 cites W2103768771 @default.
• W2807742933 cites W2109339576 @default.
• W2807742933 cites W2110464471 @default.
• W2807742933 cites W2114752093 @default.
• W2807742933 cites W2129370444 @default.
• W2807742933 cites W2129400742 @default.
• W2807742933 cites W2150915626 @default.
• W2807742933 cites W2157144029 @default.
• W2807742933 cites W2160181672 @default.
• W2807742933 cites W2162068180 @default.
• W2807742933 cites W221215209 @default.
• W2807742933 cites W2276743544 @default.
• W2807742933 cites W2288702213 @default.
• W2807742933 doi "https://doi.org/10.1002/1878-0261.12345" @default.
• W2807742933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6068346" @default.
• W2807742933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29896883" @default.
• W2807742933 hasPublicationYear "2018" @default.
• W2807742933 type Work @default.
• W2807742933 sameAs 2807742933 @default.
• W2807742933 citedByCount "10" @default.
• W2807742933 countsByYear W28077429332018 @default.
• W2807742933 countsByYear W28077429332019 @default.
• W2807742933 countsByYear W28077429332020 @default.
• W2807742933 countsByYear W28077429332021 @default.
• W2807742933 countsByYear W28077429332022 @default.
• W2807742933 countsByYear W28077429332023 @default.
• W2807742933 crossrefType "journal-article" @default.
• W2807742933 hasAuthorship W2807742933A5016777122 @default.
• W2807742933 hasAuthorship W2807742933A5020476074 @default.
• W2807742933 hasAuthorship W2807742933A5046993341 @default.
• W2807742933 hasAuthorship W2807742933A5052037513 @default.
• W2807742933 hasAuthorship W2807742933A5052823826 @default.
• W2807742933 hasAuthorship W2807742933A5053123311 @default.
• W2807742933 hasAuthorship W2807742933A5053990271 @default.
• W2807742933 hasAuthorship W2807742933A5062080961 @default.
• W2807742933 hasBestOaLocation W28077429331 @default.
• W2807742933 hasConcept C104177226 @default.
• W2807742933 hasConcept C121608353 @default.
• W2807742933 hasConcept C126322002 @default.
• W2807742933 hasConcept C170493617 @default.
• W2807742933 hasConcept C173396325 @default.
• W2807742933 hasConcept C185592680 @default.
• W2807742933 hasConcept C190283241 @default.
• W2807742933 hasConcept C2778468042 @default.
• W2807742933 hasConcept C2778690821 @default.
• W2807742933 hasConcept C2781187634 @default.
• W2807742933 hasConcept C2781249067 @default.
• W2807742933 hasConcept C502942594 @default.
• W2807742933 hasConcept C526805850 @default.
• W2807742933 hasConcept C55493867 @default.
• W2807742933 hasConcept C57074206 @default.
• W2807742933 hasConcept C62478195 @default.
• W2807742933 hasConcept C71924100 @default.
• W2807742933 hasConcept C86803240 @default.
• W2807742933 hasConcept C95444343 @default.
• W2807742933 hasConceptScore W2807742933C104177226 @default.
• W2807742933 hasConceptScore W2807742933C121608353 @default.
• W2807742933 hasConceptScore W2807742933C126322002 @default.
• W2807742933 hasConceptScore W2807742933C170493617 @default.
• W2807742933 hasConceptScore W2807742933C173396325 @default.

• next